Edinburgh Clinical Trials


For patients <60 years with moderate-severe medial compartment osteoarthritis (OA), there is uncertainty regarding the most effective treatment (surgical management with HTO or non-surgical management with structured physiotherapy), as arthroplasty in these patients is associated with a comparatively poor outcome. This trial will compare the clinical and cost-effectiveness of HTO with structured Personalised Knee Therapy (PKT) in patients <60 years with symptomatic medial compartment knee OA.

What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 50 years? (MOTION Trial)


Chief Investigator: Mr Anish Amin

Number and location of participating sites (by region/ country): UK 20 sites

EudraCT number: N/A

ISRCTN number: ISRCTN99042491


Funder: NIHR

Start and End date

Of grant award: 01 August 2022 to 31 July 2027

Of recruitment: 28 February 2023 to 31 January 2025


Current Status: Currently recruiting


Trial Website: N/A

Email: MOTION.Trial@ed.ac.uk


UK GDPR Privacy Statement: N/A


Co-sponsor Representative: http://accord.scot/


Chief Investigator

Mr Anish Amin, Consultant Trauma and Orthopaedic Surgeon, Royal Infirmary Edinburgh, Orthopaedics, 51 Little France Crescent, Edinburgh, EH16 4TJ; Anish.K.Amin@ed.ac.uk


Trial Manager: Rachel Locherty

Assistant Trial Manager: Hannah Rickman

Email: MOTION.Trial@ed.ac.uk


ECTU involvement: Trial management / Statistics / Health Economics/ Database / Randomisation service.