For patients <60 years with moderate-severe medial compartment osteoarthritis (OA), there is uncertainty regarding the most effective treatment (surgical management with HTO or non-surgical management with structured physiotherapy), as arthroplasty in these patients is associated with a comparatively poor outcome. This trial will compare the clinical and cost-effectiveness of HTO with structured Personalised Knee Therapy (PKT) in patients <60 years with symptomatic medial compartment knee OA.
What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 50 years? (MOTION Trial)
Chief Investigator: Mr Anish Amin
Number and location of participating sites (by region/ country): UK 20 sites
EudraCT number: N/A
ISRCTN number: ISRCTN99042491
Start and End date
Of grant award: 01 August 2022 to 31 July 2027
Of recruitment: 28 February 2023 to 31 January 2025
Current Status: Currently recruiting
Trial Website: N/A
UK GDPR Privacy Statement: N/A
Co-sponsor Representative: http://accord.scot/
Trial Manager: Rachel Locherty
Assistant Trial Manager: Hannah Rickman
ECTU involvement: Trial management / Statistics / Health Economics/ Database / Randomisation service.