New paper published by Michlewski Lab

E3 ubiquitin ligase TRIM25 is newly identified RNA‐binding protein which is emerging as a key factor in the innate immune response to RNA viruses.

The innate immune system is the body's first line of defense against viruses. The tripartite motif containing 25 (TRIM25) is an E3 ubiquitin ligase thought to be a key component in the activation of innate immune response. TRIM25 has recently been identified as an RNA-binding protein, raising the question of whether its RNA-binding activity is important for its role in innate immunity. Here, we review TRIM25's mechanisms and pathways in non-infected and infected cells.  This protein represents a large group of proteins with newly identified RNA-binding potential and can serve as an exemplar towards critical evaluation of protein functions in biological systems.

Original publication

Nila Roy Choudhury, Gregory Heikel and Gracjan Michlewski. WIREs RNA. 2020;e1588