MND-SMART
MND-SMART: Motor Neurone Disease Systematic Multi-Arm Adaptive Randomised Trial
The aim of this clinical trial, called MND-SMART, is to improve outcomes for people living with MND. We plan to evaluate numerous repurposed medicines over many years using a multi-arm multi-stage trial design. Multi-arm means more than one drug is tested at one time. ‘Repurposing’ is investigating if a drug that has already been approved to treat one disease may be beneficial in treating another. The trial will be conducted in four stages and only continue if the results of each stage meet pre-defined criteria. In stages 1-3 the outcome measure ALS-FRS(R), a functional scale used in MND, will be evaluated alongside the safety and tolerability of the drugs. In stage 4 we will analyse the effects of drugs on survival. The latest information on trial status and investigational treatments is available from the MND-SMART website www.mnd-smart.org
Chief Investigator: Prof Siddharthan Chandran
Number and location of participating sites / geographical scope (by region/ country): UK 12 sites
EudraCT Number: 2019-000099-41
ISRCTN number: NCT04302870 https://www.clinicaltrials.gov/ct2/show/NCT04302870
Funder: MND Scotland Euan MacDonald Centre for MND Research My Name’5 Doddie Foundation
Start and End date
Of grant award: January 2019
Of recruitment: March 2020
Current status: Currently recruiting Website: https://www.mnd-smart.org/
Participant Area: https://www.mnd-smart.org/about/participant-information
Trial Unblinding Information: The PI, or delegate with authority to unblind, will log-in to the trial database using their username and password
Sponsor: ACCORD
Chief Investigator: Prof Siddharthan Chandran, Centre for Clinical Brain Sciences, 49 Little France Crescent, Edinburgh, EH16 4SB. Siddharthan.chandran@ed.ac.uk
Trial Manager: Amy Stenson
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ECTU Involvement: Statistics / Database / Randomisation