Dr Sarah Taylor

Senior Lecture in Equine Orthopeadics

Background

Sarah graduated from the University of Edinburgh in 2001 following which she spent a year in mixed practice in North Wales before returning to the Dick vet to undertake a residency in Equine Surgery. During her residency Sarah completed a Masters degree assessing synovial fluid markers in horses with bone spavin and was also awarded the RCVS Certificate in Equine Orthopaedic Surgery in 2004. Sarah became a Diplomate of the European College of Veterinary Surgeons in 2007. She was award a Horserace Betting Levy Board Research Training Scholarship in 2009 to undertake a PhD investigating the use of mesenchymal stem cells for equine tendon disease at the University of Liverpool under the supervision of Professor Clegg.

On completion of her PhD in 2010 she returned to the Dick Vet for the second time to accept the post of Senior Lecturer in Equine Surgery. Subsequently Sarah spent a sabbatical during 2011 working as a surgeon at the Liphook Equine Hospital, Surrey. Sarah became RCVS Specialist in Equine Surgery in 2012. She has a keen clinical interest in equine sports medicine and surgery, while her research interests continue to focus on stem cells and MRI.

Qualifications

Master of Research, University of Edinburgh

Master of Equine Science

Bachelors in Veterinary Medicine & Surgery, University of Edinburgh Doctor of Philosophy (PhD), University of Liverpool

 

Professional Qualifications

RCVS Specialist in Equine Surgery

Diploma of the European College of Veterinary Surgeons (European College of Veterinary Surgeons)

Certificate in Equine Orthopaedics (Royal College of Veterinary Surgeons)

Member of the Royal College of Veterinary Surgeons

Responsibilities & affiliations

Equine Orthopaedics

Research summary

Project List

Equine Osteoarthritis

Osteoarthritis (OA) is estimated to be responsible for up to 60% of equine lameness and as such is an important cause of pain, disability and economic loss within the equine industry.

Project 1: Metabolomics as a predictor of metacarp(tarso)phalangeal subchondral bone disease in the Thoroughbred racehorse

Over the last 10 years the importance of the supporting subchondral bone beneath the joint surface has been highlighted in the development of fractures and OA in horses, yet we still know little of why certain horses sustain these injuries and other do not.

Using advanced imaging (MRI) and state of the art scientific techniques such as metabolomics (measurement of small metabolites in the joint fluid) should help to quantify how the subchondral bone contributes to these conditions with the ultimate aim being early detection and prevention. Collaboration with the University of Liverpool.

Project  2:  Does the length of time cultured at 37 degrees Celsius affect cytokine or miRNA expression of autologous conditioned serum?

Autologous conditioned serum (ACS) refers to a cytokine rich serum harvested after culturing peripheral blood with coated glass beads. ACS provides a practical alternative intra-articular corticosteroids for biological treatment of joint disease.

Culture of whole blood with the glass beads to produce ACS may lead to modifications in the transcriptomic profile that result in altered gene expression. Next generation sequencing of equine sera to allow proof of such a relationship would have wide ranging implications for the pathophysiology and treatment of osteoarthritis.

 Equine Regenerative Medicine

Project 3: Generation and biomedical application of equine induced pluripotent stem cells (Funded by the Horse Betting Levy Board, the Royal College of Veterinary Surgeons Trust, the Pet Plan Charitable Trust and The University of Edinburgh Staff Scholarship scheme)

Current research interests

Molecular pathogenesis of equine osteoarthritis and novel biological treatments using regenerative medicine (stem cells and autologous conditioned serum).

View all 21 publications on Research Explorer

BVM&S Year 4

Equine Orthopaedics

BVM&S Year 5

Final Year Rotations

All Years

MSc Equine Science