Developmental Origins of Blood Stem Cells and Leukaemia
Our group is studying leukaemia in infants as a unique, developmental disease. Complementing our other interests in how blood cells are generated during development, we are trying to understand how the properties of the foetal cell-of-origin in infant leukaemia dictates the disease phenotype and the implications this has for designing treatment strategies that are specifically tailored to the requirements of infant patients.
|Katrin Ottersbach||Principal Investigator and Senior Lecturer and UoE Chancellor’s Fellow|
|Chrysa Kapeni||Research Assistant and PhD student|
|Nada Zaidan||PhD student|
|Vasiliki Symeonidou||PhD student|
Blood stem cells, developmental haematopoiesis, infant leukaemia, MLL-AF4, miRNAs
Leukaemia mouse models, transplantation assays, haematopoietic assays