UK Centre for Mammalian Synthetic Biology

Our Members

A list of our investigators

Name Interests Affiliation E-mail
Adrian Bird   We use genetic manipulation technology to selectively ablate cells within the brain and other tissues based  on X-inactivation choice.  The results will shed light on tissue/organ plasticity and may have therapeutic implications.   School of Biological Sciences
Karl Burgess   Metabolomics, Proteomics, Bioinformatics, Industrial Biotechnology   School of Biological Sciences
Sara Buonomo   Understanding the functional relationships between DNA replication, nuclear organisation and gene expression.   School of Biological Sciences 
Elise Cachat   Engineering new synthetic gene circuits in mammalian cells: sensing modules, reporting modules and actuation modules (e.g. locomotion, apoptosis). Cells endowed with these new functions can be used to sense the presence of specific stimuli in their environment and report or act upon it.      School of Biological Sciences 
Jane Calvert   Science and Technology Studies; Responsible Research and Innovation; Philosophy of Biology; Science Policy   Science, Technology and Innovation Studies
Jamie Davies   Synthetic morphogenesis, tissue engineering, pharmacology.   CMVM (Deanery of Biomedical Sciences)
Alistair Elfick  

Standardisation in mammalian synthetic biology; metabolic metrology; engineering biology for organ-on-chip systems

  School of Engineering
William C. Earnshaw   Cell cycle, mitosis, mitotic chromosome structure, centromeres, kinetochores, epigenetics and human artificial chromosomes.   Wellcome Centre of Cell Biology/ School of Biological Sciences
Tilo Kunath   Producing next-generation human cell products for Parkinson’s research and advanced therapies using synbio approaches.   CRM/ School of Biological Sciences
Andrew Millar  

Open Research and Research Data Management, implemented locally through the Bio_RDM team (please contact, and institutionally through partnership with the University's Research Data Services.

Science policy and Research community organisation, which overlaps with Research on Research and the Science of Network Science. Implemented in collaboration with Science, Technology and Innovation Studies and Edinburgh Business School, and via Scottish and UK policy engagement.

  School of Biological Sciences
Teuta Pilizota  

We are developing tools to automate microbial culturing as well as to increase the analytical capability we can obtain during microbial culture growth. A recent start-up from our lab, OG Bio ( is commercializing some of the technology.

  School of Biological Sciences
Steven Pollard   Neural stem cells, brain cancer, transcriptional control, enhancers, gene therapy, cell therapy.   CRM/ School of Biological Sciences
Susan Rosser   CHO cell engineering, theranostics, crispr cell engineering, diagnostics and sensors.      School of Biological Sciences
Abdenour Soufi   Understanding the chromatin basis that control cellular identity. We exploit and develop synthetic biology approaches to reprogramme mammalian cells from one type to another.    CRM/ School of Biological Sciences
Peter Swain  

The systems biology of cellular decision-making, particularly the response of budding yeast to stress. ​​

  School of Biological Sciences  
Joyce Tait   Support for innovation in life sciences, including foresighting future business models and value chains, analysing the impact of regulatory systems and future regulatory adaptation, and responsible innovation    Innogen Institute