FOCUS

Fluoxetine Or Control Under Supervision (FOCUS)

The FOCUS trial is a randomised controlled trial which aims to find out whether fluoxetine given to people for six months after a stroke improves long-term recovery, even if they do not have depression.

Chief Investigator: Professor Martin Dennis

Number and location of participating sites (by region/ country): UK 91 Active sites

EudraCT number: 2011-0056616-29

ISRCTN number: 83290762

Funder: The Stroke Association

Start and End date of grant award: April 2012 - July 2018

Status: awaiting publication

FOCUS trial website:  http://www.focustrial.org.uk/ 

EFFECT trial website (Sweden):  http://www.effects.se/english

Further information: : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-015-0864-1

Mead G, Hackett ML, Lundstrom E, Murray V, Hankey GJ, Dennis M. The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: a study protocol for three multicentre randomised controlled trials. Trials. 2015 Aug 20;16. 369.

Trial Unblinding Information: Available through system. In circumstances where unblinding is necessary please refer to the protocol and follow instructions provided. Contact details are provided below.

Sponsor:  University of Edinburgh and NHS Lothian ACCORD

CI: Professor Martin Dennis; Trial Manager: Karen Innes, Room FU303E, Centre for Clinical Brain Sciences (CCBS), Chancellors Building, 49 Little France Crescent, Edinburgh. EH16 4SB focus.trial@ed.ac.uk

ECTU involvement: Database and randomisation service provision