Philip Starkey Lewis
Postdoc
Contact details
- Tel: 0131 651 9569
- Email: pstarkey@staffmail.ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
I am a post-doctoral research fellow currently working at the MRC Centre for Regenerative Medicine (University of Edinburgh). I am a pharmacologist by training having obtained my BSc (Pharmacology, 2008), MRes (Drug Safety, 2009) and PhD (Drug Safety, 2013) at the MRC Centre for Drug Safety Science based at the University of Liverpool under the supervision of Prof. Kevin Park and Dr. Chris Goldring. My research focussed on biomarker qualification and novel ex vivo models of drug-induced liver injury. In May 2014, I moved to the Centre for Regenerative Medicine to start a new challenge for the safety assessment of regenerative medicine therapies on liver tissue under the supervision of Prof. Stuart Forbes. This work comprises part of the Safety Hub of the UK Regenerative Medicines Platform. My current research interests include the determination of adverse reactions of various regenerative medicine therapies, including stem cells, macrophages and macrophage stimulating agents.
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Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes
In:
American Journal of Transplantation
DOI: https://doi.org/10.1111/ajt.16488
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
In:
EBioMedicine, vol. 62
DOI: https://doi.org/10.1016/j.ebiom.2020.103092
Research output: Contribution to Journal › Article (Published) -
TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.
In:
Journal of Hepatology, vol. n/a, pp. 1-72
DOI: https://doi.org/10.1016/j.jhep.2020.11.018
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose
In:
BMC Medical Genomics, vol. 13
DOI: https://doi.org/10.1186/s12920-020-0705-2
Research output: Contribution to Journal › Article (Published) -
Alternatively activated macrophages promotes necrosis resolution following acute liver injury
(12 pages)
In:
Journal of Hepatology, vol. 73, pp. 349-360
DOI: https://doi.org/10.1016/j.jhep.2020.02.031
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization
In:
Science Translational Medicine, vol. 12
DOI: https://doi.org/10.1126/scitranslmed.aan5907
Research output: Contribution to Journal › Article (Published) -
Macrophages as a Cell-Based Therapy for Liver Disease
In:
Seminars in liver disease
DOI: https://doi.org/10.1055/s-0039-1688502
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mesenchymal Stem Cells and Induced Bone Marrow‐Derived Macrophages Synergistically Improve Liver Fibrosis in Mice
In:
Stem Cells Translational Medicine, vol. 8, pp. 271-284
DOI: https://doi.org/10.1002/sctm.18-0105
Research output: Contribution to Journal › Article (Published) -
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
In:
Nature Communications, vol. 9
DOI: https://doi.org/10.1038/s41467-018-03299-5
Research output: Contribution to Journal › Article (Published) -
The STAT3-IL10-IL6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury
In:
Journal of Immunology, vol. 200, pp. 1169-1187
DOI: https://doi.org/10.4049/jimmunol.1701247
Research output: Contribution to Journal › Article (Published) -
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat
(9 pages)
In:
Biomarkers, vol. 22, pp. 461-469
DOI: https://doi.org/10.1080/1354750X.2016.1269131
Research output: Contribution to Journal › Article (Published) -
Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
In:
npj Regenerative Medicine
DOI: https://doi.org/10.1038/s41536-017-0017-0
Research output: Contribution to Journal › Article (Published) -
Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labelling in macrophages for magnetic resonance-based detection in vivo
In:
Cytotherapy, vol. 19, pp. 555-569
DOI: https://doi.org/10.1016/j.jcyt.2017.01.003
Research output: Contribution to Journal › Article (Published) -
Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome
In:
International Journal of Molecular Sciences, vol. 18
DOI: https://doi.org/doi:10.3390/ijms18020285
Research output: Contribution to Journal › Article (Published) -
Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells
In:
Journal of the American Society of Nephrology, vol. 27, pp. 3345-3355
DOI: https://doi.org/10.1681/ASN.2015050568
Research output: Contribution to Journal › Article (Published)