Professor Paul Digard
Chair of Virology
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
| 2006-2011 | Honorary Researcher, Cambridge University Hospitals Trust |
| 2005-2011 | Senior Lecturer |
| 2004-2005 | University Lecturer |
| 2003-2004 |
Senior Research Associate, Funded by Wellcome Trust Value in People award |
| 1995-2003 |
Royal Society University Research Fellow |
| 1993-1995 |
Research Associate, Division of Virology, Department of Pathology, University of Cambridge |
| 1989-1993 |
Fellow, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School |
Qualifications
1982-1985 St John's College, University of Cambridge, U.K. M.A.(2i.) in Natural Science
1985-1989 Division of Virology, Department of Pathology, University of Cambridge. Ph.D. in virology
Responsibilities & affiliations
PhD Student Thesis Committees
2012-presentChair: Charles Vander Broek2012-2014Advisor: Seema Jasim2012-presentChair: Dung Nguyen2012-presentAdvisor: Alexander Brown2013-present
Advisor: Andrew Mason
Other Committees etc
2012-2013 Promotions Committee, The Pirbright Institute
2012-2014 Roslin Institute, Biological Safety Committee
2012-2014 Roslin Institute Senior Management Group
2014 Acting Head of Division, Infection and Immunity
2014-Roslin Institute Bioimaging Committee
Undergraduate teaching
Lecturing
1997-presentVirology option of Pathology Part II, University of Cambridge
2000-Virology MSc. course, London School of Hygiene and Tropical Medicine. 2000-2005 Virology module, The Gulbenkian Foundation, Lisbon, Portugal. 2003-2011 Wellcome Trust 4 yr PhD program: Infection and Immunity 2005-2012 Part IB Pathology, University of Cambridge 2012-presentOne Health/Animal Biosciences MSc, University of Edinburgh 2012-presentInfectious Diseases, BSc Honours, University of Edinbugh
Practical Classes:
1985-1988 Virology practical, Pathology IB, University of Cambridge
1993-2011 Virology practical, Pathology IB, University of Cambridge. Class organiser, 2006-2011. Class of 500 students.1993-1999Virology practical, Pathology II, University of Cambridge. Class of 20 students.
2000 Virology module, The Gulkenkian Foundation, Lisbon, Portugal. Class of 12 students
Research Projects
1993-2011 Pathology Part II final year research projects, University of Cambridge
2001 Biomedical Sciences BSc course, Anglia Polytechnic University
2015 Infectious Diseases (Honours) final year research project, University of Edinburgh
Small Group Teaching
1986-1989, 2001-2013
Virology & parasitology supervisions, Pathology IB, University of Cambridge1993-2011 Virology supervisions, Pathology II, University of Cambridge
2004-2011 Virology Part II data handling sessions and paper presentations, University of Cambridge
2004 Part IB Infectious Diseases in Animals & Man, University of Cambridge
2013-present 1st year BVM&S (Vet Med), The Animal Body 2, University of Edinburgh
Research summary
Replication and pathogenesis of influenza viruses.
Current research interests
Professor Digard is a virologist who has published on herpesviruses, plus strand RNA viruses and (primarily) on influenza A virus. His laboratory is interested in the molecular and cellular biology of how influenza virus replicates, using this information to understand the basis of virus pathogenesis and host range, as well as for translational studies on antiviral drug development and virus control measures. In recent years, the group has focused on three main areas: identifying cellular pathways and viral elements involved in genome trafficking and virus assembly, on the function of the viral RNA synthesis machinery and its role in setting host range, and in identifying novel virus polypeptides, at least three of which affect virus pathogenicity. Research students Matt Smith, PhD Alice Coburn, PhD, joint with Glasgow University Rebecca Dewar, PhD Anabel Clements, PhD-
Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health
In:
Emerging Infectious Diseases, vol. 29
DOI: https://doi.org/10.3201/eid2906.221723
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
(33 pages)
In:
PLoS Pathogens, vol. 19, pp. 1-34
DOI: https://doi.org/10.1371/journal.ppat.1011357
Research output: Contribution to Journal › Article (Published) -
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
(22 pages)
In:
Genome Biology, vol. 24, pp. 1-23
DOI: https://doi.org/10.1186/s13059-023-02881-5
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility
(16 pages)
In:
Frontiers in Cellular and Infection Microbiology, vol. 13, pp. 1-17
DOI: https://doi.org/10.3389/fcimb.2023.1067993
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Comparative analysis of different inbred chicken lines highlights how a hereditary inflammatory state affects susceptibility to avian influenza virus
(19 pages)
In:
Viruses, vol. 15, pp. 1-20
DOI: https://doi.org/10.3390/v15030591
Research output: Contribution to Journal › Article (Published) -
Corrigendum: The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility
(1 page)
In:
Frontiers in Cellular and Infection Microbiology, vol. 13, pp. 1-1
DOI: https://doi.org/10.3389/fcimb.2023.1194878
Research output: Contribution to Journal › Comment/debate (Published) -
Personalised 3D printed respirators for healthcare workers during the COVID-19 pandemic
In:
Frontiers in Medical Technology, vol. 4
DOI: https://doi.org/10.3389/fmedt.2022.963541
Research output: Contribution to Journal › Article (E-pub ahead of print) -
TRIM25 inhibits influenza A virus infection, destabilises viral mRNA, but is redundant for activating the RIG-I pathway
In:
Nucleic Acids Research, vol. 50, pp. 7097-7114
DOI: https://doi.org/10.1093/nar/gkac512
Research output: Contribution to Journal › Article (Published) -
Using species A rotavirus reverse genetics to engineer chimeric viruses expressing SARS-CoV-2 spike epitopes: Heterologous viral peptide expression by rotavirus A
(25 pages)
In:
Journal of Virology, vol. 96, pp. 1-25
DOI: https://doi.org/10.1128/jvi.00488-22
Research output: Contribution to Journal › Article (Published) -
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkac512
Research output: Contribution to Journal › Article (Published)