Professor Lonneke Vervelde

Personal Chair of Veterinary Immunology &Infectious Diseases

Tel: 0131 651 9211
Fax: 0131 651 9105
Email: lonneke.vervelde@roslin.ed.ac.uk
Web: University of Edinburgh Research Explorer Profile

Street: The Roslin Institute
Easter Bush Campus
Midlothian
City
Post code: EH25 9RG

Willingness to take Ph.D. students: Yes

Biography

Background

Dr Vervelde gained a BSc and MSc in Biology (Immunology Parasitology and Ethology) at the Wageningen University The Netherlands, followed by a PhD on the immune responses in chicken to Eimeria tenella performed at the Central Veterinary Institute in Lelystad. She then went to the Institute for Animal Health in Compton to continue her work on immune responses to avian diseases, in particular infectious bursal disease virus.

In 1998 she moved to The Netherlands to the Department Parasitology and Tropical Veterinary Medicine at the Faculty of Veterinary Medicine in Utrecht to work on the mucosal immune responses of ruminants to helmnth infections. In 2003 she set up the Avian Immunology group in the Department of Infectious Diseases & Immunology investigating the immune responses to pathogens and vaccines in poultry with the ultimate goal to enhance immune-mediated resistance. In 2013 she moved ot the Roslin Institute where she is a group leader and associate professor in avian immunology.

Currently she leads research projects investigating host-pathogen interactions within the mucosal immune system aiming to define the mechanisms whereby natural immunity is achieved and how protective immunity is induced by vaccination. The research focusses on antigen presenting cells and their interaction with other cells of the innate and adaptive immune system with the overall aim to modulate these cells to improve immune mediated resistance and to understand their contribution to pathogenesis.

Qualifications

1990Doctor of Science, Cent Vet Inst Wageningen UR, Wageningen University & Research Center Eimeria tenella infections in chickens - to recognize and to be recognized1984Master of Science, Wageningen University MSc in Biology Immunology/Parasitology/Ethology

Responsibilities & affiliations

Editorial Board Veterinary Immunology and Immunopathology

Houghton Trust member travel fund committee

Roslin Institute:

Chair Poultry Users Committee

Member NARF management team

Member Bio-imaging and Flowcytometry management team

Research

Research summary

Host-pathogen interactions and immunomodulation in avian species, with a particular focus on mucosal surfaces.

Current research interests

My research group has investigated the immune responses to pathogens and vaccines in poultry with the ultimate goal to enhance immune-mediated resistance and thus improving the welfare of the animals. The overall aim is to determine how the early innate responses, with a special focus on antigen presenting cells, modulate the adaptive responses and assess their role in the induction of protective immunity, particularly at musosal surfaces. The research focuses on economically important pathogens such as avian influenza virus, infectious bronchitis virus and Eimeria species.Next to unravelling the basic host-pathogen interactions, the work included improvement of mucosal vaccination through antigen targeting and adjuvants and enhancement of gut health through feed additives.The development of new immunological tools, reagents and assays for avian immunology is another area of research. This will provide means to investigate fundamental immunological knowledge and determine immunological correlates of protection against avian diseases.Research studentsAbi BremnerCarina ConceiçãoArchana JadhavSarah KeepEsther Nash

Publications

Evaluation of Glycosylated FlpA and SodB as Subunit Vaccines Against Campylobacter jejuni Colonisation in Chickens 11 Sep 2020 In: Vaccines
DOI: https://doi.org/10.3390
Research output: Contribution to Journal › Article (Published)
Erratum: Chakraborty, P. et al. Macrophages from Susceptible and Resistant Chicken Lines have Different Transcriptomes following Marek's Disease Virus Infection. Genes 2019, 10, 74 15 Jul 2020 In: Genes, vol. 11
DOI: https://doi.org/10.3390/genes11070796
Research output: Contribution to Journal › Article (Published)
Temperature Sensitivity: A Potential Method for the Generation of Vaccines against the Avian Coronavirus Infectious Bronchitis Virus 14 Jul 2020 In: Viruses, vol. 12
DOI: https://doi.org/10.3390/v12070754
Research output: Contribution to Journal › Article (Published)
Limited Cross-Protection against Infectious Bronchitis Provided by Recombinant Infectious Bronchitis Viruses Expressing Heterologous Spike Glycoproteins 22 Jun 2020 In: Vaccines
DOI: https://doi.org/doi.org/10.3390/vaccines8020330
Research output: Contribution to Journal › Special issue (Published)
Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni 24 Jan 2020 In: Applied and Environmental Microbiology
DOI: https://doi.org/10.1128/AEM.02607-19
Research output: Contribution to Journal › Article (E-pub ahead of print)
Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung 10 Jan 2020 In: Veterinary Research, vol. 51
DOI: https://doi.org/10.1186/s13567-019-0733-0
Research output: Contribution to Journal › Article (Published)
Avian Pathogenic Escherichia coli (APEC) Strain-Dependent Immunomodulation of Respiratory Granulocytes and Mononuclear Phagocytes in CSF1R-Reporter Transgenic Chickens 10 Jan 2020 In: Frontiers in Immunology, vol. 10
DOI: https://doi.org/10.3389/fimmu.2019.03055
Research output: Contribution to Journal › Article (E-pub ahead of print)
Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses 3 Dec 2019 In: PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0225658
Research output: Contribution to Journal › Article (Published)
Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian M cells in the avian follicle-associated epithelium 22 Oct 2019 In: Frontiers in Immunology
DOI: https://doi.org/10.3389/fimmu.2019.02495
Research output: Contribution to Journal › Article (E-pub ahead of print)
Avian immune responses to virus infection Sep 2019
DOI: https://doi.org/10.21775/9781912530106
Research output: › Chapter (peer-reviewed) (Published)

View all 103 publications on Research Explorer

This article was published on 16 Sep, 2020