Dr Finn Grey
Senior Research Fellow

Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Qualifications
1998 Doctor of Philosophy (PhD), University of Cambridge
1993 Bachelor of Science, University of Glasgow
Research summary
Identifying host pathogen interactions using systems approaches
Current research interests
The Grey Lab uses cutting-edge tools to examine the interactions between the host and pathogens such as cytomegalovirus, influenza virus and African Trypanosomiasis. Pathogens interact with hosts in complex and intricate ways. Understanding how pathogens interact with the host can provide valuable information on how the pathogen replicates and teach us how the host responds to infections, ultimately leading to the development of better vaccines, drugs and treatment regimes. Systematic high throughput screens are powerful approaches that allow us to examine the role of host genes during infection. Our group uses cutting-edge high throughput approaches including small interfering RNA (siRNA) and CRISPR/Cas9 screens, arrayed interferon stimulated gene (ISG) expression libraries and microRNA target identification to discover and characterise novel host-pathogen interactions. We work on human clinical diseases including human cytomegalovirus, diseases important to livestock, and pathogens that span both human and livestock, such as influenza virus and African Trypanosomiasis.-
Comparative sensitivity and specificity of the 7SL sRNA diagnostic test for Animal Trypanosomiasis.
In:
Frontiers in Veterinary Science
Research output: Contribution to Journal › Article (Accepted/In press) -
Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
(14 pages)
In:
BMC Biology, vol. 20
DOI: https://doi.org/10.1186/s12915-021-01217-8
Research output: Contribution to Journal › Article (Published) -
Does the Zinc Finger Antiviral Protein (ZAP) shape the evolution of Herpesvirus genomes?
In:
Viruses, vol. 13
DOI: https://doi.org/10.3390/v13091857
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock
DOI: https://doi.org/10.1101/2021.09.10.459580
Research output: › Working paper (E-pub ahead of print) -
A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass
In:
Viruses, vol. 13
DOI: https://doi.org/10.3390/v13081574
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Discovering antiviral restriction factors and pathways using genetic screens
In:
Journal of General Virology, vol. 102
DOI: https://doi.org/10.1099/jgv.0.001603
Research output: Contribution to Journal › Article (Published) -
Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy
In:
Science Immunology, vol. 6
DOI: https://doi.org/10.1126/sciimmunol.abg5413
Research output: Contribution to Journal › Article (Published) -
Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion
In:
PLoS Pathogens, vol. 17
DOI: https://doi.org/10.1371/journal.ppat.1009255
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene
In:
PLoS Pathogens, vol. 16
DOI: https://doi.org/10.1371/journal.ppat.1008844
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Intra-genome variability in the dinucleotide composition of SARS-CoV-2
In:
Virus Evolution
DOI: https://doi.org/10.1093/ve/veaa057
Research output: Contribution to Journal › Article (E-pub ahead of print)