Thesis title: Multimodal MRI methods to quantify blood-brain barrier leakage in the ageing brain
MRC DTP Precision Medicine (iCase)
Year of study: 4
- Centre for Clinical Brain Sciences
- Email: C.J.Manningemail@example.com
Centre for Clinical Brain Sciences
49 Little France Crescent
- Post code
- EH16 4SB
Previously completed a Physics MPhys at Cardiff University - my final year project involved statistical comparison of BOLD and ASL MRI techniques in CVR measurement of healthy volunteers.
My current PhD involves quantifying the blood-brain barrier (BBB) leakage that occurs with cerebral small vessel disease (SVD). By using simulations to assess the effects of several physiological and technical factors e.g. reduced blood flow, restricted compartmental water exchange, and B1 inhomogeneities, suggested improvements can be made to future DCE-MRI protocols for measuring SVD-related BBB leakage. I am also working on analysing clinical DCE data from an ongoing SVD study to investigate the relationship between BBB leakage and other imaging markers of SVD such as white matter hyperintensities, and also relate leakage to SVD-associated risk factors e.g. hypertension, smoking, high cholesterol.
Joint European Stroke Organisation - World Stroke Organisation 2020 : Poster Presentation
European Stroke Conference 2021 : Presentation
UK Dementia Research Institute Early Career Researcher Conference 2021 : Presentation