Cameron Manning

Thesis title: Multimodal MRI methods to quantify blood-brain barrier leakage in the ageing brain


Previously completed a Physics MPhys at Cardiff University - my final year project involved statistical comparison of BOLD and ASL MRI techniques in CVR measurement of healthy volunteers.

My current PhD involves quantifying the blood-brain barrier (BBB) leakage that occurs with cerebral small vessel disease (SVD). By using simulations to assess the effects of several physiological and technical factors e.g. reduced blood flow, restricted compartmental water exchange, and B1 inhomogeneities, suggested improvements can be made to future DCE-MRI protocols for measuring SVD-related BBB leakage. I am also working on analysing clinical DCE data from an ongoing SVD study to investigate the relationship between BBB leakage and other imaging markers of SVD such as white matter hyperintensities, and also relate leakage to SVD-associated risk factors e.g. hypertension, smoking, high cholesterol.