Baojun Wang


2019 - present    Reader and UKRI Future Leaders Fellow, University of Edinburgh

2013 - 2019    Group Leader and Chancellor's Fellow in Synthetic Biology, University of Edinburgh

2011 - 2013    Research Associate, Imperial College London

2007 - 2011    PhD in Bioengineering, Imperial College London

2000 - 2005    BEng in Biomedical Engineering, Zhejiang University

Undergraduate teaching

Lecturer of "Gene Expression and Microbial Regulation" course for BSc Biotechnology Honours Programme.

Postgraduate teaching

Lecturer of "Tools for Synthetic Biology" course for MSc in Synthetic Biology and Biotechnology Programme. 

Open to PhD supervision enquiries?


Research summary (The Synthetic Biological Circuit Engineering Lab)

The research in our group is primarily centered around Synthetic Biology and Bioengineering at the interface of biology and engineering. The topic has significant growing application in diverse areas including industrial biotechnology, healthcare and environment. Our interests include both fundamental and applied synthetic biology. The following describes the three synergistic research themes which we are currently focusing on, i.e. the foundational technology, healthcare and industrial biotechnology applications of synthetic biology

1. Foundational synthetic gene circuits  In this area, foundational synthetic gene circuits are designed and constructed to program living cells with designer functions including novel modular and orthogonal genetic logic gates, sensors, biological processors and advanced computing and information processing circuits (towards a programmable and scalable cell-based biocomputer). The results will greatly expand the currently limited toolbox in synthetic biology. New biological circuit design principles are being developed by exploiting design principles in other engineering systems such as modularity, orthogonality, systematic characterization and modelling to increase the predictability and scalability of gene circuit design and assembly.

2. Synthetic cellular biosensors and biomanufacturing  In this area, the engineered gene networks are employed for applications including intelligent multi-input cell-based/cell-free biosensors for environmental monitoring and diagnostics, and as enabling tools to customize biologics and biomaterial manufacturing. New synthetic sensors are being developed to sense specific environmental toxins or disease related signals (pathogens, nucleic acids and cancers) with high selectivity and sensitivity. Genetic logic and analog circuits are applied to link the synthetic sensors and specialised actuators such as reporters, electron conduits and functional pathways to generate various designer output responses. Further, dynamic sensor-regulators are being constructed in microbial cell factories to allow balancing metabolism and adaptively tuning product synthesis rate.

3. Synthetic biology enabled new diagnostics and therapeutics  Here we engineer bacteriophages to selectively target gut pathogens such as Shigella flexneri that causes widespread environmental enteropathy in human gut in developing countries. On the second thread, we are developing new low-cost, simple cell-free biosensors for providing point-of-care diagnostics of target toxins and pathogens in various specimens in resource limited situations. Further, synthetic biology is used as a tool to build synthetic regulatory circuits for perturbing or mimicking their natural counterparts to aid disclosing design principles and properties of cell signalling and stress response systems, contributing to bacterial infection treatment.