Dr Zofia Lisowski
Lecturer in Veterinary Biomedicine
Contact details
Address
- Street
-
The Royal (Dick) School of Veterinary Studies and The Roslin Institute
Easter Bush Campus - City
- Midlothian
- Post code
- EH25 9RG
Background
After qualifying from the University of Liverpool School of Veterinary Sciences in 2008, Zofia worked as a veterinary surgeon at a charity veterinary hospital, Animal Care in Egypt, in Luxor providing veterinary care to working donkeys and equids. On her return to the UK, she completed an internship in equine medicine and surgery at The Bell Equine Veterinary Clinic in Kent. Following her internship, Zofia then worked in equine clinical practice in the UK before being awarded a Horserace Betting Levy Board Veterinary Research Training Scholarship to undertake a PhD at the Roslin Institute and The Royal (Dick) School of Veterinary Studies investigating equine postoperative ileus. After completing her PhD in 2018, Zofia was appointed as a Lecturer in Veterinary Biomedicine at the Royal (Dick) School of Veterinary Studies where she divides her time between teaching and research. Her research focusses on the equine immune system with a particular focus on inflammation in the gastrointestinal tract.
Qualifications
Doctor of Philosophy (PhD), University of Edinburgh, Targeting the macrophage in equine postoperative ileus
Fellow of The Higher Education Academy (FHEA)
Bachelor of Veterinary Science (BVSc), The University of Liverpool
Undergraduate teaching
Year 1
The Animal Body 1
Year 2
The Animal Body 3
The Animal Body 4
Year GEP
The Animal Body
Open to PhD supervision enquiries?
Yes
Research summary
Mucosal immunology and neuroimmune interactions
Current research interests
My research aims to understand the pathogenesis of inflammation in the gastrointestinal tract particularly in horses. Studies are concentrated on immune cell populations of the equine intestine in the steady state and disease, principally focusing on horses with colic and postoperative ileus. An additional area of study is the equine innate immune system with a focus on macrophages and understanding the equine macrophage response to LPS and how this may influence the susceptibility of the horse to endotoxaemia. I am also interested the bi-directional interaction of immune cells in the intestine with the enteric nervous system.-
Use of quantitative real-time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis externa of horses undergoing small intestinal resection
In:
Equine Veterinary Journal
DOI: https://doi.org/10.1111/evj.13429
Research output: Contribution to Journal › Article (Published) -
The equine mononuclear phagocyte system: the relevance of the horse as a model for understanding human innate immunity
In:
Equine Veterinary Journal
DOI: https://doi.org/10.1111/evj.13341
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Species-specificity of transcriptional regulation and the response to lipopolysaccharide in mammalian macrophages.
In:
Frontiers in Cell and Developmental Biology
DOI: https://doi.org/10.3389/fcell.2020.00661
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract
In:
Veterinary Immunology and Immunopathology
DOI: https://doi.org/10.1016/j.vetimm.2020.110073
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A mini-atlas of gene expression for the domestic goat (Capra hircus)
In:
Frontiers in genetics, vol. 10
DOI: https://doi.org/10.3389/fgene.2019.01080
Research output: Contribution to Journal › Article (Published) -
A mini-atlas of gene expression for the domestic goat (Capra hircus) reveals transcriptional differences in immune signatures between sheep and goats
DOI: https://doi.org/10.1101/711127
Research output: › Working paper (Published) -
A Gene Expression Atlas of the Domestic Water Buffalo (Bubalus bubalis)
In:
Frontiers in genetics
DOI: https://doi.org/10.3389/fgene.2019.00668
Research output: Contribution to Journal › Article (Published) -
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
In:
Nature Communications, vol. 10
DOI: https://doi.org/10.1038/s41467-019-11053-8
Research output: Contribution to Journal › Article (Published) -
Erratum: Pleiotropic impacts of macrophage ands microglial deficiency on development in rats with targeted mutation of the Csf1r locus (Journal of Immunology (2019) 201 (2683-2699) DOI: 10.4049/jimmunol.1701783)
(2 pages)
In:
The Journal of Immunology, vol. 202, pp. 3334-3335
DOI: https://doi.org/10.4049/jimmunol.1900420
Research output: Contribution to Journal › Comment/debate (Published) -
Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression
(15 pages)
In:
G3: Genes | Genomes | Genetics, pp. 359-373
DOI: https://doi.org/10.1534/g3.118.200810
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus
In:
The Journal of Immunology, vol. 201, pp. 2683-2699
DOI: https://doi.org/10.4049/jimmunol.1701783
Research output: Contribution to Journal › Article (Published) -
ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages
(14 pages)
In:
Frontiers in Immunology, vol. 9
DOI: https://doi.org/10.3389/fimmu.2018.02246
Research output: Contribution to Journal › Article (Published) -
Generation and characterisation of equine bone marrow-derived macrophages
Research output: Contribution to Conference › Poster (Published) -
Transcriptomic response of equine bone marrow-derived macrophages cultured in macrophage colony-stimulating factor (CSF-1) to lipopolysaccharide (LPS)
Research output: Contribution to Conference › Poster (Published) -
Activation of macrophages in the mucosa and muscularis of jejunum in horses undergoing abdominal surgery for strangulating small intestinal obstructions
Research output: Contribution to Conference › Poster (Published) -
Comparison of antibacterial and immunological properties of Mesenchymal Stem/Stromal cells from equine Bone Marrow, Endometrium and Adipose tissue
In:
Stem Cells and Development, vol. 8
DOI: https://doi.org/10.1089/scd.2017.0241
Research output: Contribution to Journal › Article (E-pub ahead of print) -
An update on equine postoperative ileus: Definitions, pathophysiology and management.
In:
Equine Veterinary Journal, vol. 50, pp. 292-303
DOI: https://doi.org/10.1111/evj.12801
Research output: Contribution to Journal › Article (Published) -
Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system
(15 pages)
In:
The Journal of Immunology, vol. 200, pp. 2209-2223
DOI: https://doi.org/10.4049/jimmunol.1701488
Research output: Contribution to Journal › Article (Published) -
Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages
In:
ImmunoHorizons, vol. 2, pp. 27-37
DOI: https://doi.org/10.4049/immunohorizons.1700073
Research output: Contribution to Journal › Article (Published) -
Distribution of macrophages in the gastrointestinal tract of horses
(1 page)
In:
Equine Veterinary Education, vol. 29, pp. 10
DOI: https://doi.org/10.1111/eve.13_12792
Research output: Contribution to Journal › Meeting abstract (Published)