Covid-19 immunity research boosted by data hub
Scientists at Edinburgh have joined forces with researchers from across the UK to boost vital studies into coronavirus antibodies and immunity.
The £4m project will pool existing UK coronavirus antibody data in one secure source to accelerate the search for treatments and inform decisions around shielding and public health restrictions.
Researchers say the data hub – called CO-CONNECT – will help them address fundamental questions about how immunity develops and how it could help prevent the virus spreading in schools and workplaces.
Widespread lockdowns were put in place in many countries in 2020 to restrict the spread of SARS-CoV-2 infection, but with these restrictions came significant social and economic consequences.
As yet, it is not known how long immunity lasts after coronavirus infection or why some people are more at risk of severe disease.
Understanding more about immunity could be key to protecting vulnerable people, limiting the spread of disease and developing targeted public health measures as the pandemic continues.
The UK is already home to coronavirus antibody datasets based on blood samples taken from volunteers with Covid-19. However, there is little consistency in how these datasets are collected and stored, limiting their usefulness.
The new initiative – supported by HDR UK and Public Health Scotland – will bring data together in a coherent and consistent way that will make it easier for scientists to quickly draw conclusions.
The project will also connect antibody data to existing healthcare records to allow research teams to find links between Covid-19 outcomes and other diseases, as well as characteristics such as age and sex.
These links are vital to inform decisions about who is most at risk of severe disease and how best to treat them.
The initiative builds on BREATHE – a health data research hub for respiratory health based at the University’s Usher Institute.
CO-CONNECT brings together 29 different organisations and 44 data sources across the UK to create a ‘one-stop’ service for trustworthy Covid-19 antibody data.
The collaboration – led by the Universities of Edinburgh, Dundee, Nottingham and Public Health England – draws on expertise in securely managing anonymous data at huge scales.
Large datasets are transforming healthcare research and initiatives like CO-CONNECT will be key to accelerating research into Covid-19 antibodies. This UK-wide initiative brings together data custodians and experts with a wealth of experience in health data management who will collaborate to develop new insights into Covid-19 and speed up the search for treatments that are so badly needed.
We are really excited to be bringing together the best of the UK’s data assets into an accessible and harmonised dataset. It will ensure leading researchers have access to the latest data and at the scale required to give definitive answers to some of the most significant questions that require an answer. We are really thankful to all the leading organisations that have come together to make this possible in the spirit of collaboration under the vision of ensuring data can help save lives.
The project is funded by UK Research and Innovation (UKRI) and the National Institute for Health Research (NIHR), through the UKRI-NIHR COVID-19 Rapid Response Rolling Call.