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Find out about our recent scientific publications.

The latest academic research publications by the Small Vessel Disease Research academic researchers.

Publications of the month: February - December 2021


Blair et al (2021) Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial

Conosole et al (2021) DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging



Moullaali et al (2021) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data

Stringer et al (2021) Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors



Wardlaw et al (2021) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies

Zhang et al (2021) Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

de Havenon et al (2021) Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities

Chagnot et al (2021) Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia

Jiménez-Sánchez et al (2021) Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis

Green C et al (2021) Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland



Vynckier et al (2021) Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study

Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis

Backhouse et al (2021) Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

Shi et al (2021) Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

Oh et al (2021) Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington’s Disease

Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production

Hamilton et al (2021) Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

Al-Shahi Salman et al (2021) Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral HemorrhageExtended Follow-up of the RESTART Randomized Clinical Trial

SoSTART Collaboration (2021) Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial



Xia et al (2021) Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial

Weather et al (2021) Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing


Wardlaw (2021) A Stroke Is a Stroke, With or Without a Visible Infarct

Procter et al (2021) Interplay between brain pericytes and endothelial cells in dementia

Habota et al (2021) Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments [version 2; peer review: 2 approved]

Bernal et al (2021) Selective Motion Artefact Reduction via Radiomics and k-space Reconstruction for Improving Perivascular Space Quantification in Brain Magnetic Resonance Imaging

Blair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project

Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production

Hamilton et al (2021) Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936



Hamilton & Wardlaw (2021) Response to Schroeter ML, Letter, Small vessel disease and social cognition

Stringer et al (2021) A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease

Wiegertjes et al (2021) Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage

Zhou et al (2021) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target

Portilla-Fernandez et al (2021) Meta-analysis of epigenome-wide association studies of carotid intima-media thickness

Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference


Valdés Hernández et al (2021) White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition

Castorina et al (2021) Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021

Morrsison & Valdés Hernández (2021) Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants



Morrison et al (2021) Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication use

Stewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis

Manning et al (2021) Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage

Wardlaw et al (2021) ESO Guideline on covert cerebral small vessel disease

van der Brink et al (2021) Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study

Buchanan et al (2021) Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936


Bernal (2021) Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imaging

Humphreys & Valdés Hernández (2021) Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans 

Valdés Hernández (2021) Human Brain Atlases across the lifespan – Anatomical Segmentations



Madole et al (2021) Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines

Bernal et al (2021) A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage

Ingala et al (2021) Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort



Valdes-Hernandez et al (2021) Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Taylor et al (2021) Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Valdes-Hernandez et al (2021) Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke

Clancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis

Liebeskind & Wardlaw (2021). Imaging advances: acute-on-chronic stroke



Verdelho et al (2021) Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee

Verdelho et al (2021) Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee – A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics

Zhou et al (2021) Low- versus Standard-dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial

Green et al (2021) Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder

Rodriguez et al (2021) Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral Hemorrhage

Stringer et al (2021) A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

Papanastasiou et al (2021) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept

View all publication of the Small Vessel Disease Research group at the Edinburgh Research Explorer

Small Vessel Disease Research publications- Edinburgh Research Explorer (external link) 


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