Bin-Zhi Qian: Tumour Microenvironment in Cancer Metastasis and Therapy Resistance

Research Programme

The role of macrophages in breast cancer distal metastasis

• Signal cascade that regulate metastasis-associated macrophages in rate limiting steps of distal metastasis: extravasation, initial survival and persistent growth.

The role of tumour microenvironment in cancer metastasis and therapy resistance

A. Integrated multi-modality imaging of novel bone metastasis models of prostate cancer.

B. Bone marrow whole mount staining of myeloid subsets (MHCII green CD11c red)

C. Ex vivo intact lung imaging showing tumour cell (blue) extravasation (exiting blood vessel red) and interaction with macrophages (green).

D. Intra-vital imaging showing heterogeneous distribution of responsive (green) and resistant (red) tumour cells upon treatment

C. Ex vivo intact lung imaging showing tumour cell (blue) extravasation (exiting blood vessel) (red) and interaction with macrophages (green).

D. Intra-vital imaging showing heterogeneous distribution of responsive (green) and resistant (red) tumour cells upon treatment.