Patrick Heun lab
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Latest publications from the lab.


Stirpe, A., and Heun, P. (2022). The ins and outs of CENP-A: Chromatin dynamics of the centromere-specific histone. Semin Cell Dev Biol. 10.1016/j.semcdb.2022.04.003. 


Bobkov, G.O.M., Huang, A., van den Berg, S.J.W., Mitra, S., Anselm, E., Lazou, V., Schunter, S., Feederle, R., Imhof, A., Lusser, A., Jansen, L.E.T., and Heun, P. (2020). Spt6 is a maintenance factor for centromeric CENP-A. Nature communications 11, 2919. 

Medina-Pritchard, B., Lazou, V., Zou, J., Byron, O., Abad, M.A., Rappsilber, J., Heun, P., and Jeyaprakash, A.A. (2020). Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. EMBO J 39, e103234. PMC7110144 

Scacchetti, A., Schauer, T., Reim, A., Apostolou, Z., Campos Sparr, A., Krause, S., Heun, P., Wierer, M., & Becker, P. B. (2020). Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms. eLife, 9, e56325. PMID: 32432549; PMCID: PMC7239659. 


Roure, V., Medina-Pritchard, B., Anselm, E., Jeyaprakash, A.A., and Heun, P. (2019). Reconstituting Drosophila centromere identity in human cells. Cell reports, 2019 Oct 8;29(2):464-479.e5. doi: 10.1016/j.celrep.2019.08.067.

Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P., Black BE., Human Artificial Chromosomes that Bypass Centromeric DNA. Cell. 2019 Jul 25;178(3):624-639.e19. doi: 10.1016/j.cell.2019.06.006. 


Kyriacou, E. and P. Heun, High-resolution mapping of centromeric protein association using APEX-chromatin fibers. Epigenetics Chromatin, 2018. 11(1): p. 68. 

Bobkov, G.O.M., N. Gilbert, and P. Heun, Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation. J Cell Biol, 2018. 217(6): p. 1957-1972. 

Anselm, E., et al., Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization. Nucleic Acids Res, 2018. 46(21): p. 11274-11286. 


Barrey, E.J. and P. Heun, Artificial Chromosomes and Strategies to Initiate Epigenetic Centromere Establishment. Prog Mol Subcell Biol, 2017. 56: p. 193-212. 


Logsdon, G.A., et al., Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol, 2015. 208(5): p. 521-31. 


Padeken, J. and P. Heun, Nucleolus and nuclear periphery: velcro for heterochromatin. Curr Opin Cell Biol, 2014. 28: p. 54-60.
Barth, T.K., et al., Identification of novel Drosophila centromere-associated proteins. Proteomics, 2014. 14(19): p. 2167-78.


Thomae, A.W., et al., A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell, 2013.27(4): p. 412-24.
Padeken, J., et al., The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus. Molecular cell, 2013. 50(2): p. 236-49.


Olszak, A.M., et al., Heterochromatin boundaries are hotspots for de novo kinetochore formation. Nature cell biology, 2011.13(7): p. 799-808.
Mendiburo, M.J., et al., Drosophila CENH3 is sufficient for centromere formation. Science, 2011. 334(6056): p. 686-90.