Dyslexia and ADHD often occur together in people and they share many genes in common – links which make them distinct from developmental and mental health diagnoses such as autism, bipolar disorder and schizophrenia, a study shows.
Genetic links
This study, led by the University of Edinburgh, is the first to explore the genetic links to dyslexia – believed to affect 10 per cent of the population – in the context of neurodevelopmental and psychiatric traits.
The findings could help in tailoring targeted educational, employment and wellbeing support systems for people with dyslexia or ADHD, experts say.
The findings aid understanding of the biology behind dyslexia – a difficulty with reading and spelling – and ADHD, a condition associated with difficulty concentrating, hyperactivity and impulsivity.
Public datasets
Researchers at the University of Edinburgh analysed large public anonymised datasets of genetic data on 10 neurodevelopmental and psychiatric conditions from the Psychiatric Genomics Consortium, along with dyslexia genetic statistics from an analysis of around one million people in collaboration with 23andMe, a genomics and biotechnology company.
They used a statistical tool to find clusters of genetically similar traits for dyslexia and 10 neurodevelopmental and psychiatric traits including ADHD, anorexia nervosa and Tourette syndrome.
Genetic regions
They conducted more detailed analyses to identify specific genetic regions that overlap between dyslexia and ADHD.
Among the 10 psychiatric traits included in the study, five genetically linked clusters known as latent genomic factors were identified.
ADHD was more strongly related to an attention and learning difficulties factor than with factors related to neurodevelopmental traits like autism and Tourette syndrome.
Follow-up analyses of the attention and learning difficulties factor identified 49 genetic regions and 174 genes shared between dyslexia and ADHD, of which 40 regions and 121 genes have not been previously identified.