Dr Don Mahad
Senior Clinical Lecturer
- Centre for Clinical Brain Sciences
- Anne Rowling Regenerative Neurology Clinic
Contact details
- Email: don.mahad.ed.ac.uk
Background
I spend 80 percent of my time on research and 20 percent on clinical care (general neurology and multiple sclerosis) as a consultant neurologist. I have developed expertise in the diagnosis, treatment and symptomatic management of MS patients through the MS clinical care physician fellowship awarded by National Multiple Sclerosis Society.
Research summary
We study bioenergetics, in particular the role of mitochondria in the pathophysiology of neurodegeneration, demyelination and remyelination failure with a focus on progressive multiple sclerosis.
Research group members
- Graham Campbell - Postdoctoral Fellow
Sources of funding
- Wellcome Trust
- MS Society
- Scottish Funding Council
-
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis
In:
Neuropathology and Applied Neurobiology, pp. e12851
DOI: https://doi.org/10.1111/nan.12851
Research output: Contribution to Journal › Article (Published) -
MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis
In:
Brain Communications
DOI: https://doi.org/10.1093/braincomms/fcab249
Research output: Contribution to Journal › Article (Published) -
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
In:
Acta Neuropathologica
DOI: https://doi.org/10.1007/s00401-020-02252-5
Research output: Contribution to Journal › Article (Published) -
Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial
In:
Lancet Neurology, vol. 19, pp. 988-997
DOI: https://doi.org/10.1016/S1474-4422(20)30347-1
Research output: Contribution to Journal › Article (Published) -
Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability
In:
Multiple Sclerosis and Related Disorders, vol. 47, pp. 102630
DOI: https://doi.org/10.1016/j.msard.2020.102630
Research output: Contribution to Journal › Article (Published)