Clinical and laboratory research to study mechanisms of neurodegeneration and repair in multiple sclerosis, motor neurone disease, dementias and degenerative eye conditions.
Our research is a fusion of collaborative laboratory and clinical activity. In the lab, the researchers study disease mechanisms using human stem cell, cellular and in vivo models. Clinical research aims to understand disease incidence and course, undertake early-phase clinical trials and improve quality of life for patients.
The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.
|Clinical phenotyping, registers and trials||Siddharthan Chandran|
|Voice-banking and voice reconstruction (with Informatics)||Siddharthan Chandran|
|Cognition in multiple sclerosis: linked psychological testing and brain imaging (with Bak/Chandran)||Peter Connick|
|Stratified medicine: right person, right treatment, right time||Peter Connick|
|Advanced ocular imaging as a window into the brain||Baljean Dhillon|
|Multi-modal retinal scanning for diagnostic & therapeutic biomarker discovery in multiple sclerosis||Tom MacGillivray|
|Cognitive disorders diagnosis, audit, research and treatment register||Suvankar Pal|
|Clinical trials in Alzheimer's disease||Craig Ritchie|
|Motor neurone disease clinical register and DNA bank||Robert Swingler|
|Dementias Platform UK: Identification of dementia outcomes||Cathie Sudlow|
|Human stem cell modelling of neurons and glia in motor neurone disease||Siddharthan Chandran|
|Inflammation, neurodegeneration and repair in mouse models of multiple sclerosis||Siddharthan Chandran|
|Mechanisms of neuroinflammation||David Hunt|
|Systematic review and meta-analysis of interventions tested in animal models of AD or MS||Malcolm Macleod|
|The role of mitochondria in neuronal damage in multiple sclerosis||Don Mahad|
Clinical research is undertaken through the Anne Rowling Regenerative Neurology Clinic.
Motor neurone disease (MND) research is undertaken through the Euan MacDonald Centre for MND Research.
Multiple sclerosis (MS) research is undertaken through the MS Society-funded Edinburgh Centre for MS Research.
The Centre for Dementia Prevention brings together clinical, basic science and social science expertise to understand and reduce risk associated with dementia.
Professor Siddharthan Chandran and Professor Joanna Wardlaw are programme leads at the UK DRI Edinburgh, which is led by Professor Giles Hardingham.