Centre for Clinical Brain Sciences

Neurodegenerative conditions

Clinical and laboratory research to study mechanisms of neurodegeneration and repair in multiple sclerosis, motor neurone disease, dementias and degenerative eye conditions.

Human neural stem cells in culture

Our research is a fusion of collaborative laboratory and clinical activity. In the lab, the researchers study disease mechanisms using human stem cell, cellular and in vivo models. Clinical research aims to understand disease incidence and course, undertake early-phase clinical trials and improve quality of life for patients.

The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.

Example clinical research projects
Research theme PI
Clinical phenotyping, registers and trials Siddharthan Chandran
Voice-banking and voice reconstruction (with Informatics) Siddharthan Chandran
Cognition in multiple sclerosis: linked psychological testing and brain imaging (with Bak/Chandran) Peter Connick
Stratified medicine: right person, right treatment, right time Peter Connick
Advanced ocular imaging as a window into the brain Baljean Dhillon
Multi-modal retinal scanning for diagnostic & therapeutic biomarker discovery in multiple sclerosis Tom MacGillivray
Cognitive disorders diagnosis, audit, research and treatment register Suvankar Pal
Clinical trials in Alzheimer's disease Craig Ritchie
Dementias Platform UK: Identification of dementia outcomes Cathie Sudlow


Example laboratory research projects
Research theme PI
Human stem cell modelling of neurons and glia in motor neurone disease Siddharthan Chandran
Inflammation, neurodegeneration and repair in mouse models of multiple sclerosis Siddharthan Chandran
Mechanisms of neuroinflammation David Hunt
Systematic review and meta-analysis of interventions tested in animal models of AD or MS Malcolm Macleod
The role of mitochondria in neuronal damage in multiple sclerosis Don Mahad


Anne Rowling Regenerative Neurology Clinic

Clinical research is undertaken through the Anne Rowling Regenerative Neurology Clinic.

Euan MacDonald Centre for MND Research

Motor neurone disease (MND) research is undertaken through the Euan MacDonald Centre for MND Research.

Edinburgh Centre for MS Research

Multiple sclerosis (MS) research is undertaken through the MS Society-funded Edinburgh Centre for MS Research.

Edinburgh Centre for MS Research

Centre for Dementia Prevention

The Centre for Dementia Prevention brings together clinical, basic science and social science expertise to understand and reduce risk associated with dementia.

Centre for Dementia Prevention website

UK Dementia Research Institute at the University of Edinburgh

Professor Siddharthan Chandran and Professor Joanna Wardlaw are programme leads at the UK DRI Edinburgh, which is led by Professor Giles Hardingham.

News April 2017: CCBS researchers join UK Dementia Research Institute