Neurodegenerative conditions
Clinical and laboratory research to study mechanisms of neurodegeneration and repair in multiple sclerosis, motor neurone disease, dementias and degenerative eye conditions.
Our research is a fusion of collaborative laboratory and clinical activity. In the lab, the researchers study disease mechanisms using human stem cell, cellular and in vivo models. Clinical research aims to understand disease incidence and course, undertake early-phase clinical trials and improve quality of life for patients.
The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.
| Research theme | PI |
|---|---|
| Rowling CARE - a Scotland-wide register for people with neurodegenerative disorders and their carers | Siddharthan Chandran |
| Speak:Unique - Voicebanking and voice reconstruction (with Informatics) | Siddharthan Chandran |
| Cognition in multiple sclerosis: linked psychological testing and brain imaging (with Bak/Chandran) | Peter Connick |
| FutureMS: predicting the course of multiple sclerosis | Peter Connick |
| Advanced ocular imaging as a window into the brain | Baljean Dhillon |
| Multi-modal retinal scanning for diagnostic & therapeutic biomarker discovery in multiple sclerosis | Tom MacGillivray |
| Clinical Audit, Research and Evaluation in Motor Neurone Disease (CARE-MND) | Suvankar Pal |
| Cognitive disorders diagnosis, audit, research and treatment register | Suvankar Pal |
| Clinical trials towards prevention & early diagnosis of dementia, e.g. EPAD & PREVENT | Craig Ritchie |
| Dementias Platform UK: Identification of dementia outcomes | Cathie Sudlow |
| Research theme | PI |
|---|---|
| Human stem cell modelling of neurons and glia in motor neurone disease | Siddharthan Chandran |
| Inflammation, neurodegeneration and repair in mouse models of multiple sclerosis | Siddharthan Chandran |
| Mechanisms of neuroinflammation | David Hunt |
| Systematic review and meta-analysis of interventions tested in animal models of AD or MS | Malcolm Macleod |
| The role of mitochondria in neuronal damage in multiple sclerosis | Don Mahad |
Anne Rowling Regenerative Neurology Clinic
Clinical research is undertaken through the Anne Rowling Regenerative Neurology Clinic.
Euan MacDonald Centre for MND Research
Motor neurone disease (MND) research is undertaken through the Euan MacDonald Centre for MND Research.
Edinburgh Centre for MS Research
Multiple sclerosis (MS) research is undertaken through the MS Society-funded Edinburgh Centre for MS Research.
MS Society Edinburgh Centre for MS Research
Centre for Dementia Prevention
The Centre for Dementia Prevention brings together clinical, basic science and social science expertise to understand and reduce risk associated with dementia.
Centre for Dementia Prevention website
UK Dementia Research Institute at the University of Edinburgh
Professor Siddharthan Chandran, Professor Joanna Wardlaw and Professor Josef Priller are programme leads at the UK DRI Edinburgh, which is led by Professor Giles Hardingham (Centre for Discovery Brain Sciences).
News April 2017: CCBS researchers join UK Dementia Research Institute