Centre for Clinical Brain Sciences
Edinburgh Neuroscience and CCBS logos

Neurodegenerative conditions

Clinical and laboratory research to study mechanisms of neurodegeneration and repair in multiple sclerosis, motor neuron disease, Parkinson's, dementias and degenerative eye conditions.

Human neural stem cells in culture

Our research is a fusion of collaborative laboratory and clinical activity. In the lab, the researchers study disease mechanisms using human stem cell, cellular and in vivo models. Clinical research aims to understand disease incidence and course, undertake early-phase clinical trials and improve quality of life for patients.

The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.


Example laboratory research projects
Research theme PI
Human stem cell modelling of neurons and glia in motor neuron disease Siddharthan Chandran
Inflammation, neurodegeneration and repair in mouse models of multiple sclerosis Siddharthan Chandran
Mechanisms of neuroinflammation David Hunt
Systematic review and meta-analysis of interventions tested in animal models of AD or MS Malcolm Macleod
The role of mitochondria in neuronal damage in multiple sclerosis Don Mahad


Anne Rowling Regenerative Neurology Clinic

Clinical research is undertaken through the Anne Rowling Regenerative Neurology Clinic.

Euan MacDonald Centre for MND Research

Motor neuron disease (MND) research is undertaken through the Euan MacDonald Centre for MND Research.

Euan MacDonald Centre for Motor Neuron Disease Research website

Gordon Aikman Awards

We administer the Gordon Aikman Award, which is funded by MND Scotland and Scottish Government. This is an annual award to improve the lives of people affected by motor neuron disease.

Gordon Aikman Award webpage


Edinburgh Centre for MS Research

Multiple sclerosis (MS) research is undertaken through the MS Society-funded Edinburgh Centre for MS Research.

MS Society Edinburgh Centre for MS Research

Edinburgh Dementia Prevention

Edinburgh Dementia Prevention brings together clinical, basic science and social science expertise to understand and reduce risk associated with dementia.

Centre for Dementia Prevention website

Dundee and Edinburgh Parkinson's Research Initiative

The Universities of Dundee and Edinburgh have joined forces to help deliver new treatments for people with Parkinson's and accelerate access to clinical trials.

Dundee and Edinburgh Parkinson's Research Initiative

UK Dementia Research Institute at the University of Edinburgh

Professor Siddharthan Chandran, Professor Joanna Wardlaw and Professor Josef Priller are programme leads at the UK DRI Edinburgh, which is led by Professor Giles Hardingham (Centre for Discovery Brain Sciences).

News April 2017: CCBS researchers join UK Dementia Research Institute