Molecular/cellular biology & disease modelling
CCBS research spans the spectrum of molecular and cellular biology through to in vivo disease modelling.
From molecules to behaviour
We investigate the inner workings of neurons, glia and other cell-types: from the molecules that make up protein complexes at the synapse, through state-of-the-art microscopy of cells in a dish, to the electrophysiology of nerve conduction, and behaviour in the whole animal.
Some of our disease modelling work uses human stem cells:
| Project | Disease | PI |
|---|---|---|
| Mouse models of inflammation, neurodegeneration & repair | multiple sclerosis | Siddharthan Chandran |
| Large-scale molecular analyses of multiprotein complexes at the synapse (Genes2Cognition) | cognition, learning & memory | Seth Grant |
| New diagnostic tests and biomarkers for prion diseases and other protein mis-folding disorders | prion diseases | Alison Green |
| Molecular analysis of synaptic plasticity, cognition, learning and memory | cognition, learning & memory | Noboru Komiyama |
| The role of mitochondria in neuronal damage | multiple sclerosis | Don Mahad |
| Receptor modulation induced by electrical fields in the synaptic cleft | synaptic biology | Sergiy Sylantyev |
| Mechanisms of memory consolidation and reconsolidation | learning & memory | Szu-Han Wang |