Dr Cristina Esteves
Senior Research Fellow
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Undergraduate teaching
Animal Body 4
Veterinary Public Health (previous)
Postgraduate teaching
MSc - Animal Biosciences
MSc - Infectious Diseases and One Health (previous)
Open to PhD supervision enquiries?
Yes
Areas of interest for supervision
Students
PhD students
Alex Moxom
Amira Aburza
Thomas Thrower
Julia Falk
Susan Dan-Jambo
Yennifer Cortes-Araya
MSc by Research/IDOH
Daina Chakma
Berik Kaliullayev
Patrick Lennard
Hlaing Phyo
Emma Weatherall
other MSc programmes (since 2014)
Katharina Grabowski
Emma Bullen-Mehta
Amanda Mayoral
Viktorija Avilkina
Yennifer Cortes-Araya
Simone Mesquita
Juan Pesantez
Lucy Dawson
Vet Students (since 2014)
Dana Fuller
Blake Klein
Georgina Brown
Rebecca McCall
Tim Menghini
Research summary
Research projects:
- Mesenchymal Stem/Stromal cells (MSCs) as novel tools for combating antimicrobial resistance in companion animals (horses and dogs) and livestock (cattle)
- Developing novel stem cell approaches towards next-generation regenerative therapies
- Involvement of Mesenchymal Stem/Stromal cells in Mycobacterium infection
- Exploiting stem cell and gene editing technologies towards discovery of genetic variants important for muscle development and meat production
- Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth
-
Characterization of canine adipose and endometrium-derived Mesenchymal Stem/Stromal Cells and their response to lipopolysaccharide
(8 pages)
In:
Frontiers in Veterinary Science, pp. 1-8
DOI: https://doi.org/10.3389/fvets.2023.1180760
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Women in Veterinary Regenerative Medicine: 2021
(2 pages)
In:
Frontiers in Veterinary Science, vol. 9, pp. 1-2
DOI: https://doi.org/10.3389/fvets.2022.1085747
Research output: Contribution to Journal › Editorial (Published) -
KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction
In:
The Journal of Physiology, vol. 600, pp. 1771-1790
DOI: https://doi.org/10.1113/JP281647
Research output: Contribution to Journal › Article (Published) -
Differentiation potential of Mesenchymal Stem/Stromal cells is altered by Intrauterine Growth Restriction
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.558905
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Farmer and veterinary practices and opinions related to fertility testing and pregnancy diagnosis of UK dairy cows
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.564209
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL
In:
Journal of Pediatrics, vol. 220, pp. 249-253
DOI: https://doi.org/10.1016/j.jpeds.2019.12.054
Research output: Contribution to Journal › Article (Published) -
Farmer and veterinary practices and opinions related to the diagnosis of mastitis and metabolic disease in UK dairy cows
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.00127
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Relationships between size, steroidogenesis and miRNA expression of the bovine corpus luteum
In:
Theriogenology
DOI: https://doi.org/10.1016/j.theriogenology.2019.10.033
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mesenchymal stem/stromal cells - A novel therapeutic tool against infection
Research output: Contribution to Conference › Abstract (Published) -
Analyses of bovine luteal fractions obtained by FACS reveals enrichment of miR-183-96-182 cluster miRNAs in endothelial cells
In:
Reproductive Biology and Endocrinology, vol. 17
DOI: https://doi.org/10.1186/s12958-019-0484-9
Research output: Contribution to Journal › Article (Published)
Invited speaker
Esteves CL, Cortés-Araya Y, Hlaing P, Rink E, Aurich C, Donadeu FX (2022) Plenary Presentation. Exploring the tissue regeneration properties of endometrial Mesenchymal Stem/Stromal Cells. International Congress on Animal Reproduction. Bologna, Italy.
Esteves, CL. (2021) Mesenchymal Stem/Stromal Cells and pericytes in domestic animals: properties and potential. Department of Veterinary Science, University of Conception, Chile.
Esteves, CL. (2021) Mesenchymal stem/stromal cells and pericytes from veterinary species. Faculty of Veterinary and Animal Sciences, University of Chile.
Esteves CL. (2019) Plenary Presentation. Mesenchymal Stem/Stromal Cells - a Novel Therapeutic Tool Against Infection. Tissue Engineering and Regenerative Medicine International Society – Europe. Rhodes, Greece.
Esteves CL. (2016) A novel method for sorting equine MSC subpopulations: isolation and characterization of pericytes and adventitial cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.
Esteves CL, Kelly V, Bégay V, Man TY, Lillico SG, Morton NM, Leutz A, Seckl JR, Chapman KE. (2011) Dietary down-regulation of 11β-HSD1; role of C/EBPβ and Endoplasmic Reticulum Stress. UK Adipose Tissue Discussion Group, University of Cambridge, UK.
Esteves CL. (2010) Regulation of 11β-HSD1 transcription by C/EBPβ isoforms (LIP,LAP) in adipose tissue. The Roslin Institute, Edinburgh.
Organiser
Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting – Session chair - Veterinary session, 2023
Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting – Organizer - Veterinary session, 2019-
Participant
Oral Presentations
Cortés-Araya Y, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX (2019) Developmental programming of muscle progenitor cell fate by foetal growth restriction. British Society of Animal Science Annual Conference. Edinburgh, UK.
Rink E, Amilon K, Cortes-Araya Y, Esteves CL, Watson E, Aurich C, Donadeu FX. (2017) Exploring the potential of endometrial MSCs for veterinary regenerative medicine. Tissue Engineering and Regenerative Medicine European Chapter Meeting, Davos, Switzerland.
Esteves CL, Peault B, Donadeu FX. (2016) Characterization and regenerative potential of equine pericytes. The Second Havemeyer Conference on Regenerative Medicine. Bonita Springs, FL, USA.
Esteves CL. (2016) A novel method for sorting equine MSC subpopulations: isolation and characterization of pericytes and adventitial cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.
Esteves CL. (2016) Mesenchymal stem/stromal cells, pericytes et al. The Roslin Institute Seminars. University of Edinburgh.
Esteves CL, Sheldrake T, Sawson L, Menghini T, Khan N, Péault B, Donadeu FX. (2015) Equine bone marrow and adipose tissue mesenchymal stem/stromal cells putatively derive from perivascular stem cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Boston, MA, USA.
Esteves CL. (2012) Transcriptional regulation of 11β-HSD1 in adipose. University/BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Esteves CL, Róg-Zielińska EA, Kelly V, Nixon M, Seckl JR, Chapman KE. (2011) Transcriptional regulation of 11b-hydroxysteroid dehydrogenase type 1 by pro-inflammatory cytokines is mediated by C/EBPβ. The Endocrine Society’s 93rd Annual Meeting ENDO, Boston, USA.
Esteves CL. (2011) Transcriptional regulation of 11β-HSD1 – C/EBPβ, pro-inflammatory cytokines and metabolism. University/BHF Centre for Cardiovascular Science, University of Edinburgh.
Esteves CL, Kelly V, Man TY, Seckl JR, and Chapman KE. (2010) Dietary regulation of 11b-HSD1 in adipose tissue is mediated by the C/EBPβ isoforms LAP and LIP. The Endocrine Society’s 92nd Annual Meeting ENDO, San Diego, California, USA.
Esteves CL. (2003) Aspartic proteinases: action on milk. Department of Biochemistry, University of Coimbra, Portugal.
Esteves CL, Lucey JA, Pires E. (2001) Rheological properties of rennet-induced gels made from coagulants of vegetable origin and chymosin. Annual meeting of the American Dairy Science Association. Indianapolis, Indiana. USA. Journal of Dairy Science Abstracts (suppl 1) 84:85
Posters
Appleby B, Paterson G, Donadeu FX, Esteves CL (2021) Mesenchymal Stem Cells as Novel Tools for Combating Antimicrobial Resistance in Dogs. Research Student Day. The Roslin Institute, Edinburgh, UK.
Thrower T, Dan-Jumbo S, Lillico S, Esteves CL, Donadeu FX (2021) Exploiting stem cell and gene editing technologies towards discovery of genetic variants important for muscle development and meat production. Research Student Day. The Roslin Institute, Edinburgh, UK.
Dan-Jumbo SO, Cortes-Araya Y, Esteves CL, Davey M, Lillico S, Donadeu FX (2021) Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth. Research Student Day. The Roslin Institute, Edinburgh, UK.
Falk J, Esteves CL, Farquharson C, Benchoua A, Suruge P, Donadeu FX (2021) Developing novel stem cell approaches towards next-generation regenerative therapies. Research Student Day. The Roslin Institute, Edinburgh, UK.
Dan-Jumbo SO, Cortes Y, Lillico S, Esteves CL, Donadeu FX. (2020) Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth and development. The British Society for Animal Science meeting, Nottingham.
Weatherall E, Alvinika V, Black K, Cortes-Araya Y, Dan-Jumbo S, Stenhouse C, Donadeu FX, Esteves CL (2020) Mesenchymal Stem/Stromal cell (MSC) tissue regeneration potential may be developmentally programmed. Society for Reproduction and Fertility - Fertility 2020 meeting. Edinburgh, UK.
Developmental programming of porcine muscle progenitor cell fate by foetal growth restriction (FGR). Society for Reproduction and Fertility - Fertility 2020 meeting. Edinburgh, UK.
Dan-Jumbo SO, Cortes Y, Esteves CL, Davey M, Lillico S, Donadeu FX. (2019) Investigating the effects of intrauterine growth restriction (IUGR) on myogenic and adipogenic progenitor cell populations in pigs. Research Student Day. The Roslin Institute, Edinburgh, UK.
Cortés-Araya Y, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX. (2019) Developmental programming of porcine muscle progenitor cell fate by foetal growth restriction. Research Student Day. The Roslin Institute, Edinburgh, UK.
Mohammed BT, Esteves CL, Donadeu FX. (2019) Isolation of different bovine luteal cell fractions using. Society for Reproduction and Fertility - Fertility 2019 meeting. Birmingham, UK.
Weatherall E, Cortes Y, Donadeu FX, Esteves CL. (2018) Characterization of porcine adipose Mesenchymal Stem/Stromal Cells (MSCs) in Intrauterine growth restriction. Adipose Tissue Discussion Group meeting. The University of Edinburgh, Edinburgh, UK.
Cortes Y, Amilon K, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX. (2018) Developmental programming of muscle stem cell fate by intrauterine growth restriction (IUGR). Society for the Study of Reproduction. New Orleans, USA.
Weatherall E, Cortes Y, Donadeu FX, Esteves CL. (2018) Characterisation of Mesenchymal Stem/Stromal cells (MSCs) and Pericytes from Porcine Adipose Tissue; The Effects of Intrauterine Growth Restriction. Research Student Day. The Roslin Institute, Edinburgh, UK.
Dan-Jumbo S, Cortes Y, Esteves CL, Davey M, Donadeu FX. (2018) Programming of myogenic and adipogenic progenitor cells in utero by Intrauterine growth restriction (IUGR) in pigs. Research Student Day. The Roslin Institute, Edinburgh, UK.
McCall R, Donadeu FX, Esteves CL. (2017) Effects of Intrauterine growth retardation on adult stem cell development in pigs. Vet Choice. Veterinary Research Program, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.
*Cortes Y, Amilon K, Stenhouse C, Adesina O, Ashworth C, Esteves CL, Donadeu FX. (2017) The effects of intrauterine growth restriction (IUGR) on muscle development in pigs -towards novel targets to improve pig production. Student Day. The Roslin Institute, Edinbugrh, UK. *poster competition - 2nd prize
Amilon KR, Cortes YA, Mendonca C, Fitzgerald JR, Donadeu FX, Esteves CL. (2016) Antibacterial effects of equine mesenchymal stem cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.
Esteves CL, Sheldrake T, Sawson L, Menghini T, Khan N, Péault B, Donadeu FX. (2015) Equine mesenchymal stem/stromal cells putatively derive from perivascular stem cells. Annual meeting of the International Society for Stem Cell Research, Stockholm, Sweden.
Rink E, French H, Watson E, Aurich C, Esteves CL, Sheldrake T, Donadeu FX. (2015) Equine endometrial mesenchymal stromal/stem cells: isolation, culture and gene expression profiles. Annual meeting of the International Society for Stem Cell Research, Stockholm, Sweden.
Rink E, French H, Watson E, Aurich C, Esteves CL, Sheldrake T, Donadeu FX. (2015) Isolation and culture of equine endometrial mesenchymal stromal cells. 48th Annual Meeting the Society for the Study of Reproduction (SSR), Puerto Rico, USA.
Menghini T, Dawson L, Esteves CL, Donadeu FX. (2014) Localisation and characterisation of mesenchymal stem cells in equine tissues. Vet Choice. Veterinary Research Program, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.
Zhang Z, Esteves CL, Turban S, Manwani K, Brown O, Man T-Y, Seckl JR, Chapman KE. (2013) Tissue-specific knock-out of 11β-HSD1 affects adipocyte size and fibrosis in mice with diet-induced obesity. Young Life Scientists' Symposium 2013: Cardiovascular Medicine: Bridging clinical and basic researchers, British Pharmacological Society, London.
Esteves CL, Schauer S, Sontake S, Donadeu FX. (2013) Profiling of miRNA regulators of granulosa cell function during follicle development on mares. Society for the Study of Reproduction 46th annual meeting, Montreal, Canada.
*Coutinho AE, Kipari T, Zhang Z, Esteves C, Gilmour JS, Cailhier J-F, Hughes J, Seckl JR, Savill JS, Chapman KE. (2011) Dynamic regulation of 11b-hydroxysteroid type 1 in neutrophils during an inflammatory response. The Endocrine Society’s 93rd Annual Meeting ENDO, Boston, USA. *poster competition -1st prize
Esteves CL, Róg-Zielińska EA, Kelly V, Nixon M, Seckl JR, Chapman KE. (2010) Transcriptional regulation of 11b-hydroxysteroid dehydrogenase type 1 by pro-inflammatory cytokines. UK Adipose Tissue Discussion Group, University of Oxford, UK.
*Esteves CL, Kelly V, Man JY, Lillico SG, Morton NM, Seckl JR, Champan KE. (2010) The C/EBPb isoforms, LIP and LAP, mediate dietary regulation of 11b-HSD1 in mouse adipose tissue. Cardiovascular Development/Stem Cells Workshop and Centre for Cardiovascular Science Symposium day, University of Edinburgh, UK. * poster competition -2nd prize
Esteves CL, Kelly V, Man JY, Lillico SG, Morton NM, Seckl JR, Champan KE. (2010) The C/EBPb isoforms mediate the down-regulation of 11b-HSD1 in mouse adipose tissue fed high-fat diet. Diabetes and obesity: getting to the heart of the matter. The Royal Society of Edinburgh, UK.
*Esteves CL, Kelly V, Man JY, Seckl JR, Champan KE. (2009) Relative levels of the C/EBPb isoforms, LAP and LIP, may underpin high fat diet down-regulation of 11b-HSD1 in mouse adipose tissue. Adipose Tissue Discussion Group Meeting. AstraZeneca, Macclesfield, UK. * poster competition -1st prize
Esteves CL, Morton NM, Seckl JR, Champan KE. (2008) C/EBP isoforms and 11b-HSD1 levels are altered in the adipose tissue of obese mice. Centre for Cardiovascular Science Symposium Day. University of Edinburgh, UK.
Esteves CL, Morton NM, Seckl JR, Champan KE. (2008) Differential changes in C/EBP isoforms may underpin tissue-specific dysregulation of 11b-HSD1 with high fat feeding. Society for Endocrinology BES 2008 Meeting. Harrogate, UK.
Esteves CL, Morton NM, Seckl JR, Champan KE. (2007) Is there a role for C/EBP transcription factors in 11b-HSD1 regulation in obesity? Centre for Cardiovascular Science Symposium Day, University of Edinburgh, UK.
Esteves CL, Jones B, Clegg S. (2004) Biofilm formation in mixed infections of Salmonella enterica Serovar Typhimurium and Escherichia coli on epithelial cells. American Society for Microbiology 104th General Meeting. New Orleans, USA.
Esteves CL, Jones B, Clegg S. (2003) Biofilm formation of Salmonella enterica serovar Typhimurium and Escherichia coli. Midwest Microbial Pathogenesis Conference. Iowa City, USA.
Esteves CL, Lucey JA, Pires E. (2003) Effect of pH of milk on gels produced by plant coagulants and chymosin. Institute of Food Technologists Annual Meeting. Chicago, USA.
Esteves CL, Lucey JA, Hyslop, DB, Pires E. (2002) Effect of temperature on the gelation properties of rennet-induced gels made from plant coagulants and chymosin. 26th International Dairy Congress. Paris, France.
Esteves CL, Lucey JA, Gunasekaran S, Pires E. (2000) Rheological evaluation of milk gels formed with chymosin and vegetable rennets. Institute of Food Technologists Annual Meeting. Dallas, USA.
Esteves C, Gunasekaran S, Olson N, Pires, E. (1999) Rheological Characterization of Milk Gelation Using Vegetable Coagulants and Chymosin. The Society of Rheology 71th Annual Meeting. Madison, USA.
Esteves C, Pereira A, Schultz J, Pires E. (1998) Two Mediterranean Vegetable Rennets - Ability to Coagulate Cow Milk. 25th International Dairy Congress. Aarhus, Denmark.
Veríssimo P, Ramalho-Santos M, Esteves C, Faro C, Pires E. (1996) A comparative study on the aspartic proteinases from different species of Cynara. X Congresso Nacional de Bioquímica. Universidade do Minho, Braga, Portugal.
Esteves CL, Veríssimo PC, Faro CJ, Pires EV. (1995) Biochemical characterization of the vegetable rennets from the flowers of cardoon: comparison to calf rennet. 1995 Annual meeting of American Dairy Science Association. Cornell University, Ithaca, New York, USA.
MSc Curriculum Developer/Coordinator
Roslin Academic Lead for Gujarat Biotechnology University (GBU) 2021-
Panel Member
The Foundation for Science and Technology (FCT), Animal and Veterinary Sciences and Agro-Food Biotechnology- Individual Call to Scientific Employment Stimulus, Portugal (2022)
Research Proposals Reviewer
MITACS, Canada. Research proposal reviewer (2022)
PhD Thesis - International external referee
Department of Physiology and Biochemistry of Animal Nutrition, University of Granada, Spain. (2022)
Editor
Associate Editor, Frontiers in Veterinary Science, Veterinary Regenerative Medicine, 2021-
Guest Editor, Frontiers in Veterinary Science, Veterinary Regenerative Medicine – Women in Science , 2022
Reviewer Board, Animals, 2021-
Review Editor, Frontiers in Veterinary Science - 2015-2021