Doireann Gordon
Thesis title: Developing a decision-making toolkit for the personalised treatment of inflammatory bowel disease
MRC Precision Medicine DTP iCASE Studentship with Genentech
Year of study: 4
- Centre for Inflammation Research
- Deanary of Clinical Science
- College of Medicine and Veterinary Medicine
Contact details
- Email: D.C.Gordon@sms.ed.ac.uk
PhD supervisors:
Address
- Street
-
Institute for Regeneration and Repair (IRR)
Edinburgh BioQuarter
4-5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
My passion lies within data science and its applications to human health and disease. Beyond my PhD, I am eager to develop my career in a data science environment with a focus on health and medicine.
Currently, my work focuses on biomarker discovery in inflammatory bowel disease (IBD) using activity-based fluorescent probes.
Qualifications
B.A. Microbiology, Trinity College Dublin, Ireland (First Class Honours)
Research summary
My PhD project utilises a patented fluorescent probe to detect GzmB activity in IBD patients. For the first few years of my project, we optimised this probe for use in clinical samples. We then quantified GzmB activity in IBD patient samples from the GIDAMPs/MUSIC trials lead by Dr. Gwo-tzer Ho. Finally, we are using this data to develop GzmB activity as a biomarker of IBD, utilising routinely collected clinical data in our multivariate analysis.
I am also conducting post-hoc analysis of several clinical trials, in which I am investigating granzymes and their roles as potential biomarkers in IBD.