MRC Centre for Inflammation Research
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Dr Gwo-Tzer Ho

My research is focused on 2 main questions: 1. What are the molecular factors that drive and maintain the abnormal mucosal inflammation in Crohn’s disease and Ulcerative Colitis? 2. How do we translate this understanding to develop new, and to improve current, medical treatments?

Dr Gwo-Tzer Ho

MRC Clinician Scientist and Honorary Consultant Gastroenterologist

  • MRC Centre for Inflammation Research
  • Research Theme - Immune modulation and regulation of inflammation

Contact details

Background

Crohn’s disease (CD) and ulcerative colitis (UC) are common chronic inflammatory bowel diseases (IBD) with significant impact on morbidity, mortality and socio-economic costs. The global prevalence is increasing sharply with projected global disease burden of 20-30 million IBD cases by 2025. Present best therapies are based on the narrow principle of inhibiting downstream inflammatory pathways (eg, cytokines and inflammatory cell migration). Complete mucosal healing (total resolution of inflammation and restoration of full mucosal restitution) however, is achieved only in 50% in our best treatment. My work is focused on identifying and developing novel therapeutic approaches in IBD

Research Overview

My overarching research aim is to translate new knowledge of immune and inflammatory mucosal mechanisms into new therapeutic approaches in IBD. I work very closely with dedicated IBD clinicians, biologists, immunologists and drug development teams with a strong focus on direct studies on human IBD along with in vivo colitis work. Major mechanistic themes are:

  1. Gut derived mucosal damage-associated molecular patterns (DAMPs)
  2. Mitochondrial dysfunction and ROS-signalling
  3. Metabolic programing of the mucosal immune response

Biographical Overview

I trained in Medicine in Glasgow (MBChB 1997 and MRCP 2000), and moved to Edinburgh to undertake my PhD with Jack Satsangi (2000-2003). I completed my specialty training in gastroenterology and internal medicine in Edinburgh (2003-2008) and was awarded an MRC Clinician Scientist Fellowship award (2009-2015). During this time, I trained under Balfour Sartor in University of North Carolina, Chapel Hill, USA (2009-2010) focusing on mucosal immunology in IBD, and moved to the MRC Centre for Inflammation Research in 2011 to establish my laboratory here. I continue to care for individuals with IBD at the Western General Hospital.

Mitochondrial DNA as ancient danger signals in IBD – Dr Gwo-tzer Ho's interview for Inflammatory Bowel Disease journal, February 2018

Could the cause of inflammation be in our own cells? – Dr Gwo-tzer Ho's work in Crohn's and Colitis UK 10-year Research Report

Precision Medicine in Inflammatory Bowel Disease – American Journal of Gastroenterology interview with Editor Professor Lacy

Gene that affects cell power supply may hold key to bowel disease – Interview with Mhairi Stuart, BBC Scotland Radio and STV News (May 2017)

Faulty energy supply and leaky gut – a new potential cause for IBD’ – Press coverage (Times, Scotsman, Daily Mail +15 other national and international media

Honours and Awards

  • 2016  Fellow of Royal College of Physicians (Edinburgh)
  • 2009  Medical Research Council Clinician Scientist Fellowship
  • 2008  United European Gastroenterology Rising Star Award
  • 2007  British Society of Gastroenterology CORE Research Prize
  • 2006  European Crohn's and Colitis Organization (ECCO) Researcher Award for UK
  • 2004-6  American Gastroenterology Association Abstracts of Distinction (3 awards)

Alumni

  • Dr Ray Boyapati (2015-2017): Consultant Gastroenterologist, Melbourne
  • Dr Arina Tamborska (2016): Academic Fellow, King’s College London

Collaborators

  • Professor Balfour Sartor: University of North Carolina, Chapel Hill, USA
  • Professor Jack Satsangi: University of Oxford, UK

Sources of Funding

More information on funding at Gwo-Tzer Ho's Research Explorer profile.