Dr Marc Vendrell
Marc Vendrell's lab studies dynamic activatable fluorophores for real-time imaging of key molecular events in cancer and inflammation.
- Nicole Barth - OPTIMA CDT PhD student co-supervised with Ian Dransfield (email)
- Sam Benson - Medical Research Scotland PhD student (email)
- Cecilia Boz - OPTIMA CDT PhD student co-supervised with Nik Hirani
- Fabio De Moliner - Post-doctoral research associate (email)
- Doireann Gordon - DTP Precision Medicine co-supervised with Gwo-tzer Ho
- Lorena Mendive-Tapia - Post-doctoral research associate (email)
- Evita Ning - OPTIMA CDT PhD student co-supervised with Karen Faulds (email)
- Abigail Reese - PhD Student co-supervised with Henry McSorley
- Jamie Scott - OPTIMA CDT PhD student (Scottish Funding Council) (email)
Emily Thompson - PhD Student co-supervised with Gwo-tzer Ho
Clara Vergez - OPTIMA CDT PhD student co-supervised with Marc Dweck
Jinling Wang - PhD student
Kelly Wood - OPTIMA SOFI PhD student co-supervised with Mathew Horrocks
Optical imaging enables the acquisition of molecular information from biological systems in situ and in real time. My lab works on the development of dynamic activatable fluorophores as novel chemical tools to address fundamental biological questions and translate them to clinical research. Our group combines expertise in peptide and organic chemistry, cell imaging, molecular biology and fluorescence spectroscopy, and we collaborate with biologists, immunologists and clinicians in a highly interdisciplinary environment.
The aim of our research is to develop dynamic activatable fluorophores (DYNAFLUORS) as enabling chemical tools to interrogate key events associated to cancer and inflammation. We generate our DYNAFLUORS through a multidisciplinary approach that involves organic and peptide chemistry, cell biology, high-resolution imaging and medicine. DYNAFLUORS are excellent optical probes because their fluorescent signal is triggered only after they interact with target molecules (e.g. proteins, enzymes) or in specific microenvironments (eg organelles, pH gradients). Our approach leads to high signal-to-noise ratios with increased sensitivity, which enables their use in small concentrations reducing any potential adverse effects and facilitating clinical translation.
Here there are some examples of our DYNAFLUORS:
PhagoGreen, an activatable cell-permeable probe for imaging phagocytic macrophages in vivo (Reproduced from J. Am. Chem. Soc. 2013, 135, 16018-21).
Time-lapse movie showing the phagosomal localization of PhagoGreen in transgenic zebrafish with mCherry-labeled macrophages.
Time-lapse movie of an actively engulfing macrophage, where the mature phagosome is brightly green fluorescent while the newly formed phagosome is devoid of green fluorescence.
The Trp-BODIPY amino acid enables fluorogenic labelling of peptides for enhanced live-cell imaging.
Marc graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in synthetic fluorophores for non-invasive optical imaging. In 2012 he started his independent career as MRC Academic Fellow at the University of Edinburgh with the vision to translate fluorescent probes to the clinic. He is a Lecturer in Biomedical Imaging and his main research interest is the development of activatable fluorophores for imaging cancer and inflammation. He has over 50 publications in chemical biology and imaging, including eight international patents. His research has been recognised with several awards: SEQT Young Investigator Award (2007), SBIC Chairman's Prize (2010) and the Marie Curie CIG (2013).
Honours and Awards
2002: PhD Studentship (Spanish Government) 2005: PhD International Exchange Studentship (Spanish Government) 2007: SEQT XIII Young Investigator Award 2010: SBIC Chairman's Prize 2012: MRC Academic Fellowship 2013: Marie Curie Fellowship 2016: ChemComm Emerging Investigator 2017: ERC Consolidator Grant 2017: Elected Fellow of the Royal Society of Chemistry 2018: Postgraduate Certificate in Academic Practice (PgCAP)
- Hira Ale (Research assistant 2014): Research assistant, King's College London
- Alejandro Jose (MSc student 2014): Medical student, University of St Andrews
- Nicola Kielland (Visiting postdoc 2014): Postdoctoral Fellow, University of Barcelona
- Lorena Mendive-Tapia (Visiting PhD student 2015): PhD student, University of Barcelona
- Can Zhao (PhD student 2012-2015): Research Associate, University of Manchester
- Thalia Perez-Suarez (MSc student 2015): Medical student
- Ryan Treadwell (BSc student 2016)
- Aaron King (MSc student 2016)
- Daniel Tritton (MSc student 2016)
- Antonio Delgado (Visiting PhD student 2016)
- Claudia Garcia-Guzman (PhD student 2013-2017)
- Emma Alexander (MSc student 2017)
- Vivian Ho (MSc student 2017)
- Yi Xin Tan (BSc student 2017)
- Zhigao Yi (Visiting PhD student 2018)
- Zhi Ming Cheng (Visiting PhD student 2018)
- Ramon Subiros-Funosas (Postdoc 2015-2018)
- Professor Mark Bradley
- Professor Young-Tae Chang
- Dr Kev Dhaliwal
- Dr Karen Faulds
- Dr Yi Feng
- Professor Margaret Frame
- Professor Chris Haslett
- Professor Uwe Himmelreich
- Dr Takanori Kitamura
- Professor Rodolfo Lavilla
- Dr Kaustabh Kumar Maiti
- Dr Richard Mellanby
- Professor Karl Oparka
- Professor Jeff Pollard
- Professor Nick Read
- Professor Greetje Vande Velde
Sources of Funding
- Marie Curie Actions
- Scottish Funding Council
- Fundacion Alfonso Martin Escudero
- Medical Research Scotland
- Royal Society