How Do Human Disease Mutations Influence Targeted Protein Degradation?
Supervisor: Dr Andrew Wood
Despite recent advances in our understanding of human disease biology, many critical disease proteins remain beyond the reach of drug design. Targeted protein degradation provides a new approach to target such proteins using small molecules that accelerate the rate of destruction by the ubiquitin proteasome system. This project will use protein degradation biosensors in combination with genome editing, mutational scanning and protein engineering to better understand how common mutations in human oncogenes influence the activity of protein degrader drugs.