Publications
Current list of publications from the department of Hepatology
Papers
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Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomedicine & Pharmacotherapy. 2019 Vol 111. doi.org/10.1016/j.biopha.2019.01.020
https://www.sciencedirect.com/science/article/pii/S0753332218372676
- Letter to the editor: ‘Human based systems: Mechanistic NASH modelling just around the corner?’ Pharmacol Res. 2018 Nov;137:280-281. doi: 10.1016/j.phrs.2018.09.028
https://www.sciencedirect.com/science/article/pii/S1043661818313525?via%3Dihub
- Nondestructive optical toxicity assays of 3D liver spheroids with optical coherance tomography. Adv Biosystems. 2018 Volume2, Issue3 doi.org/10.1002/adbi.201700212
https://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201700212
- Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver. Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541
https://www.nature.com/articles/srep37541
- Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):30-37. doi: 10.1111/bcpt.12631
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225883/
- Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. Lipids Health Dis. 2016 Jul 2;15:114. doi: 10.1186/s12944-016-0283-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930558/
- Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model. Sci Rep. 2015 Dec 3;5:17455. doi: 10.1038/srep17455
https://www.ncbi.nlm.nih.gov/pubmed/26632255
- Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events? Lipids Health Dis. 2015 Aug 10;14:86. doi: 10.1186/s12944-015-0069-3
https://www.ncbi.nlm.nih.gov/pubmed/26256740
- (1)H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy. World J Hepatol. 2015 Jun 28;7(12):1701-7. doi: 10.4254/wjh.v7.i12.1701.
https://www.ncbi.nlm.nih.gov/pubmed/26140090
- Toxicology of ZnO and TiO2 nanoparticles on hepatocytes: impact on metabolism and bioenergetics. Nanotoxicology. 2015 Feb;9(1):126-34. doi:10.3109/17435390.2014.895437.
https://www.ncbi.nlm.nih.gov/pubmed/24708275
- Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro. Sci Rep. 2013;3:2735. doi: 10.1038/srep02735
https://www.ncbi.nlm.nih.gov/pubmed/24061220
- Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis. Liver Int. 2012 Aug;32(7):1079-92. doi: 10.1111/j.1478-3231.2012.02775.x.
https://www.ncbi.nlm.nih.gov/pubmed/22429485
- Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure. World J Gastroenterol. 2011 Mar 21;17(11):1457-61. doi: 10.3748/wjg.v17.i11.1457.
https://www.ncbi.nlm.nih.gov/pubmed/21472104
- Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure. BMC Gastroenterol. 2010 Mar 30;10:34. doi: 10.1186/1471-230X-10-34.
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-34
Abstracts/Posters
