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GALA Trial - General anaesthetic versus local anaesthetic for carotid surgery (2008)

GALA was a multicentre randomised trial assessing the relative risks of stroke, cardiac events and death following carotid endarterectomy under either general or local anaesthesia.

ISRCTN registry #00525237

Trial dates


co-Chief Investigators

Mr Michael J Gough Consultant Vascular Surgeon, The General Infirmary at Leeds

Professor Charles Warlow University of Edinburgh

Protocol and forms


1: Sanders RD, Graham C, Lewis SC, Bodenham A, Gough MJ, Warlow C; GALA Trial Investigators. Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial. Br J Anaesth. 2012 Sep;109(3):361-7. doi:10.1093/bja/aes164. Epub 2012 Jun 17.

2: Gomes M, Soares MO, Dumville JC, Lewis SC, Torgerson DJ, Bodenham AR, Gough MJ, Warlow CP; GALA Collaborative Group. Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial). Br J Surg. 2010 Aug;97(8):1218-25. doi: 10.1002/bjs.7110.

3: GALA Trial Collaborative Group, Lewis SC, Warlow CP, Bodenham AR, Colam B, Rothwell PM, Torgerson D, Dellagrammaticas D, Horrocks M, Liapis C, Banning AP, Gough M, Gough MJ. General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet. 2008 Dec 20;372(9656):2132-42. doi: 10.1016/S0140-6736(08)61699-2. Epub 2008 Nov 27.

4: Gough MJ, Bodenham A, Horrocks M, Colam B, Lewis SC, Rothwell PM, Banning AP, Torgerson D, Gough M, Dellagrammaticas D, Leigh-Brown A, Liapis C, Warlow C. GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery. Trials. 2008 May 21;9:28. doi: 10.1186/1745-6215-9-28.

5: Dellagrammaticas D, Lewis S, Colam B, Rothwell PM, Warlow CP, Gough MJ; GALA trial collaborators. Carotid endarterectomy in the UK: acceptable risks but unacceptable delays. Clin Med (Lond). 2007 Dec;7(6):589-92. doi: 10.7861/clinmedicine.7-6-589.