Completed studies and trials
An archive of key research studies & clinical trials undertaken in CCBS. This page is still being populated.
Third international stroke trial (IST-3)
IST-3 was a randomised controlled trial to assess the benefits and harms of intravenous thrombolysis with the clot-busting drug alteplase within 6 h of acute ischaemic stroke. The trial involved 3035 patients from 12 countries. The trial demonstrated that alteplase treatment reduced long-term disability, significantly increased the likelihood of independence, and improved quality of life in stroke survivors of all ages for up to 18 months after treatment.
FOCUS trial - Fluoxetine Or Control Under Supervision
The FOCUS trial was a randomised controlled trial that aimed to find out whether fluoxetine given to people for six months after a stroke improves long-term recovery, even if they do not have depression. 3127 participants were recruited from 103 hospitals across the UK. The results did not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
The CLOTS trials - Clots in Legs Or sTockings after Stroke
CLOTS was a family of multicentre randomised controlled trials testing external compression devices (e.g.stockings and intermittent pneumatic compression) for deep vein thrombosis (DVT) prevention in acute stroke patients. A total of more than 8500 stroke patients participated, from over 100 hospitals around the word. The trials showed that compression stockings do not reduce the risk of DVT after stroke, but that intermittent pneumatic compression is effective. The results have had a profound impact on the treatment of stroke patients around the world.
The FOOD Trials - Feed Or Ordinary Diet in stroke
The FOOD trial was a family of three multicentre trials to evaluate feeding policies in patients with a recent stroke. A total of 5033 patients who had been admitted to hospital with a recent stroke were enrolled in the trials at 131 hospitals in 18 countries. The findings did not support routine supplementation of the hospital diet; that early tube feeding may substantially reduce the risk of dying after stroke; and that better functional outcomes resulted from feeding via NG tube than PEG tube.