Centre for Clinical Brain Sciences
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Completed studies and trials

An archive of key research studies & clinical trials undertaken in CCBS. This page is not intended to be comprehensive.

REstart or STop Antithrombotics Randomised Trial (RESTART) (2021)

RESTART tested whether antiplatelet therapy can be safely re-started in patients who have survived an intracerebral haemorrhage.

FOCUS trial - Fluoxetine Or Control Under Supervision (2019)

FOCUS trial logo
The FOCUS trial was a randomised controlled trial that aimed to find out whether fluoxetine given to people for six months after a stroke improves long-term recovery, even if they do not have depression.

The CLOTS trials - Clots in Legs Or sTockings after Stroke (2015)

CLOTS trial logo
CLOTS was a family of multicentre randomised controlled trials testing external compression devices (e.g.stockings and intermittent pneumatic compression) for deep vein thrombosis (DVT) prevention in acute stroke patients.

Third international stroke trial (IST-3) (2013)

IST3 logo
IST-3 was a randomised controlled trial to assess the benefits and harms of intravenous thrombolysis with the clot-busting drug alteplase within 6 h of acute ischaemic stroke.

GALA Trial - General anaesthetic versus local anaesthetic for carotid surgery (2008)

GALA trial logo
GALA was a multicentre randomised trial assessing the relative risks of stroke, cardiac events and death following carotid endarterectomy under either general or local anaesthesia.

The FOOD Trials - Feed Or Ordinary Diet in stroke (2005)

FOOD trial logo
The FOOD trial was a family of three multicentre trials to evaluate feeding policies in patients with a recent stroke.