Centre for Engineering Biology

Funding boost for ZYTHERA project team

ZYTHERA (enZYme THERApeutics), a research project led by a team of University of Edinburgh scientists, is engineering enzyme replacement therapies (ERTs) for lysosomal storage diseases (LSDs) using generative artificial intelligence (AI).

The team has been awarded £74,600 in funding from Scotland’s national economic development agency, Scottish Enterprise.


The ZYTHERA team is being led by Dr Giovanni Stracquadanio, Senior Lecturer in Synthetic Biology and co-director of the Edinburgh Genome Foundry (EGF), and Professor Susan Rosser, also co-director of EGF and Chair of Synthetic Biology in the School of Engineering, who developed the protein expression system.

The technology was developed as part of Dr Stracquadanio’s £1.4 million UKRI EPSRC Fellowship, and draws on Professor Rosser’s pioneering expertise in mammalian synthetic biology and biologics manufacturing.


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