Keisuke Kaji Research Group
Biology of reprogramming
The Kaji group aims to understand the mechanisms of reprogramming induced pluripotent stem cells (iPSCs) to improve the technology as well as to apply the knowledge to generate different cell types.
Aims and areas of interest
Recently a technology to generate pluripotent stem cells from differentiated somatic cells has been developed using defined transcription factors. Similarly, different cellular identity conversions from one type to the other have also been achieved by exogenous expression of master transcription factors. However, the biological mechanism underlying the process of reprogramming has not been elucidated well, and the resulting cell types are often not fully functional. Our group aims to understand the mechanism of the reprogramming, improve the technology and generate fully functional cell types for medicine.
Meryam Beniazza (Deputy Head of Single-cell Multi-omics)
My Linh Huynh (Postdoctoral Research Fellow)
Van Anh Vo (Research Fellow)
Karen Ching (PhD Student)
Jeriha Jakob (PhD Student)
Tam Ka Chung (MScR Student)