Professor Richard Meehan
Group Leader
- MRC Human Genetics Unit
- MRC Institute of Genetics & Molecular Medicine
Contact details
- Email: richard.meehan@igmm.ed.ac.uk
Background
RM is a genetics graduate of TCD (Dublin) and has been studying DNA methylation dynamics for over 25 years. Research landmarks include the identification of methyl-CpG binding proteins (MeCP1 and MeCP2), non-catalytic roles for DNMT1 and alternate hypotheses regarding DNA methylation reprogramming in development and disease states. He is currently a Professor at the MRC Human Genetics Unit in Edinburgh and investigating how 5-hydroxymethylcytosine profiling can be used as a cell identifier.
Qualifications
Bachelor of Science, Trinity College Dublin Doctor in Philosophy, University of Edinburgh Molecular Genetic Analysis of Hepatic Cytochrome P-450s.
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DNA methylation as a genomic marker of exposure to chemical and environmental agents.
In:
Current opinion in chemical biology, vol. 45
DOI: https://doi.org/10.1016/j.cbpa.2018.02.006
Contribution to journal › Review article (Published) -
A reassessment of DNA-immunoprecipitation-based genomic profiling
In:
Nature Methods
DOI: https://doi.org/10.1038/s41592-018-0038-7
Contribution to journal › Article (Published) -
Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells
In:
Philosophical Transactions of the Royal Society B: Biological Sciences
DOI: https://doi.org/10.1098/rstb.2017.0362
Contribution to journal › Article (E-pub ahead of print) -
Investigation into the role of the germline epigenome in the transmission of glucocorticoid programmed effects across generations
In:
Genome Biology
DOI: https://doi.org/10.1186/s13059-018-1422-4
Contribution to journal › Article (Published) -
A cell/cilia cycle biosensor for single cell kinetics reveals persistence of cilia after the G1/ S transition is a general property in cells and mice
In:
Developmental Cell
DOI: https://doi.org/10.1016/j.devcel.2018.10.027
Contribution to journal › Article (Published) -
Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD
In:
Wellcome Open Research
DOI: https://doi.org/10.12688/wellcomeopenres.12199.1
Contribution to journal › Article (E-pub ahead of print) -
Mobilization of LINE-1 Retrotransposons is Restricted by Tex19.1 in Mouse Embryonic Stem Cells
In:
eLIFE
DOI: https://doi.org/10.7554/eLife.26152
Contribution to journal › Article (E-pub ahead of print) -
Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration
In:
Nature
DOI: https://doi.org/10.1038/nature23015
Contribution to journal › Article (Published) -
Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis
In:
Current Opinion in Toxicology, pp. 62-70
DOI: https://doi.org/10.1016/j.cotox.2017.06.005
Contribution to journal › Review article (E-pub ahead of print) -
Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer
In:
Epigenetics
DOI: https://doi.org/10.1080/15592294.2017.1300729
Contribution to journal › Article (Published)