Professor Richard Meehan
Group Leader
- MRC Human Genetics Unit
- MRC Institute of Genetics & Molecular Medicine
Contact details
- Email: richard.meehan@igmm.ed.ac.uk
Background
RM is a genetics graduate of TCD (Dublin) and has been studying DNA methylation dynamics for over 25 years. Research landmarks include the identification of methyl-CpG binding proteins (MeCP1 and MeCP2), non-catalytic roles for DNMT1 and alternate hypotheses regarding DNA methylation reprogramming in development and disease states. He is currently a Professor at the MRC Human Genetics Unit in Edinburgh and investigating how 5-hydroxymethylcytosine profiling can be used as a cell identifier.
Qualifications
Bachelor of Science, Trinity College Dublin Doctor in Philosophy, University of Edinburgh Molecular Genetic Analysis of Hepatic Cytochrome P-450s.
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Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkaa529
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
In:
BMC Biology, vol. 18
DOI: https://doi.org/10.1186/s12915-020-0752-3
Research output: Contribution to Journal › Article (Published) -
DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
In:
Cell Reports, vol. 29, pp. 1974-1985.e6
DOI: https://doi.org/10.1016/j.celrep.2019.10.031
Research output: Contribution to Journal › Article (Published) -
Non-alcoholic fatty liver disease (NAFLD) is associated with dynamic changes in DNA hydroxymethylation Epigenetics
In:
Epigenetics
DOI: https://doi.org/10.1080/15592294.2019.1649527
Research output: Contribution to Journal › Article (Published) -
Dynamics and Mechanisms of DNA Methylation Reprogramming
DOI: https://doi.org/10.1016/B978-0-12-814879-2.00002-9
Research output: › Chapter (Published) -
A cell/cilia cycle biosensor for single cell kinetics reveals persistence of cilia after the G1/ S transition is a general property in cells and mice
In:
Developmental Cell
DOI: https://doi.org/10.1016/j.devcel.2018.10.027
Research output: Contribution to Journal › Article (Published) -
DNA methylation as a genomic marker of exposure to chemical and environmental agents.
In:
Current opinion in chemical biology, vol. 45
DOI: https://doi.org/10.1016/j.cbpa.2018.02.006
Research output: Contribution to Journal › Review article (Published) -
A reassessment of DNA-immunoprecipitation-based genomic profiling
In:
Nature Methods
DOI: https://doi.org/10.1038/s41592-018-0038-7
Research output: Contribution to Journal › Article (Published) -
Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells
In:
Philosophical Transactions of the Royal Society B: Biological Sciences
DOI: https://doi.org/10.1098/rstb.2017.0362
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Investigation into the role of the germline epigenome in the transmission of glucocorticoid programmed effects across generations
In:
Genome Biology
DOI: https://doi.org/10.1186/s13059-018-1422-4
Research output: Contribution to Journal › Article (Published)