Professor Seth Grant
Professor of Molecular Neuroscience
- 1984, Graduated from Sydney University with a Bachelor of Science (Medicine) in Physiology, Bachelor of Medicine and Bachelor of Surgery
- 1985-1989, Postdoctoral Fellow at Cold Spring Harbor Laboratory with Douglas Hanahan
- 1989-1994, Postdoctoral Fellow with Eric Kandel at Columbia University
- 1994, Centre for Genome Research at Edinburgh University
- 2000, Professor of Molecular Neuroscience, Edinburgh University
- 2003, Principal Investigator at the Wellcome Trust Sanger Institute in Cambridge
- 2011, Professor of Molecular Neuroscience , University of Edinburgh
- Additional appointments: John Cade Visiting Professor at Melbourne University, Honorary Professorship at Cambridge University and elected Fellow of the Royal Society of Edinburgh
The long-term aim is to understand the fundamental mechanisms of behaviour and how these mechanisms are involved in brain disease.
The research has focussed on the study of genes and proteins that control the synapses between nerve cells. Multiprotein machines comprising many different protein components are responsible for basic innate and learned behaviours and dysfunction in many brain diseases.
Recent work shows that these mechanisms are conserved between mice and humans opening new avenues for diagnosis and therapeutic discoveries. The Genes to Cognition programme has generated a large amount of data and tools that are freely available.
Research group members
- Noboru Komiyama: Senior Lecturer
- Emma Sigfridsson: Lab Manager
- Malikmohamed Yousuf: Postdoctoral Fellow
- Zhen (Ricky) Qiu : Image Analysis Developer
- Ragini Gokhale: Informatics Engineer
- Babis Koniaris: Lab programmer/Software Engineer
- Edita Bulovaite: PhD Student
- Dimitra Koukaroundi: PhD Student
- Shalandra Wood: PhD Student
- Gabor Varga: Research Assistant
- Bev Notman: Research Assistant
Sources of funding
The Grant lab is currently funded by the Wellcome Trust, European Research Council & Simons Initiative for the Developing Brain.
Cell‐type specific visualization and biochemical isolation of endogenous synaptic proteins in mice
NMDA receptor modulation of glutamate release in activated neutrophils
Synapse diversity and synaptome architecture in human genetic disorders
Comprehensive behavioral analysis of heterozygous Syngap1knockout mice
Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor