Professor Martin Taylor
Martin is interested in understanding how new DNA sequence changes arise and the consequences of those changes for human health. Many of the insights come from investigating the record of past evolution, using "the light of evolution" to explore the human genome. His main aims are centred around three interlinked themes: of Understanding mutational processes, interpretation of genetic variation and the evolution of gene regulation.
Prior to establishing the group in Edinburgh, Martin worked at the EMBL, European Bioinformatics Institute (EBI), with Dr Nick Goldman on the application of evolutionary models to understand genome evolution. Before this he was at the Wellcome Trust Centre for Human Genetics, at the University of Oxford, with Professor Richard Mott providing bioinformatics support to multiple research groups and pursuing his own research interests in evolutionary genomics. Martin maintained active participation in the international FANTOM consortium through each of these positions. During his PhD studites, Martin worked with Professor David Porteous on the characterisation of a chromosomal translocation that segregated with major mental illness, contributing to the discovery of the DISC1 gene. He obtained a BSc (hons, 1st) in Genetics from the University of Liverpool.
Doctor of Philosophy (PhD), University of Edinburgh Comparative and molecular characterisation of a schizophrenia susceptibility locus
Bachelor of Science, University of Liverpool
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions
Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma
Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types
The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome
Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq
Homozygous loss-of-function variants in European cosmopolitan and isolate populations
Exome Sequencing to Detect Rare Variants Associated With General Cognitive Ability