Mark Gray (BVM&S MSc VetSci Cert SAS MRCVS PhD)
Lecturer in Large Animal Research Surgery
- The Royal (Dick) School of Veterinary Studies
- THE UNIVERSITY OF EDINBURGH
Contact details
- Email: mark.gray@ed.ac.uk
Address
- Street
-
The Royal (Dick) School of Veterinary Studies
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Background
Graduating from the Royal (Dick) School of Veterinary Stuies in 2004, I initialy worked in the north east of England in mixed practice. Working at the PDSA in Middlesbrough I developed an interest in surgery which led me to complete the RCVS certificate in small animal surgery in 2011. Following the completion of my Master by Research at the Univirsity of Edinburgh in 2013, I worked as an orthopaedic veterinary surgeon in the East Neuk of Fife. But my interest in research again drew me back to Edinbugh to do a PhD, investigating the in vivo and in vitro methods to improve the use of radiotherapy in human and veterinary patients.
Following a short stint as a Research Assistant within The University of Edinburgh, I am now employed as a a lecturer in lare animal research surgery at the Veterinary School and Roslin Institute. I am working in the Large Animal Research and Imaging Facility at the Easter Bush Campus.
Qualifications
Ph.D. Molecular and Clinical Medicine. September 2015-2019
- Funded by a scholarship awarded by The University of Edinburgh
M.Sc. by research. September 2012-November 2013
- Funded by a scholarship awarded by The University of Edinburgh. Graduated with distinction
Certificate in Small Animal Surgery. January 2008-September 2011
- Royal College of Veterinary Surgeons
Bachelor of Veterinary Medicine and Surgery. September 1999-June 2004
- The University of Edinburgh
Responsibilities & affiliations
Member of the Royal College of Veterinary Surgeons
Research summary
- My PhD was part of a £5.2M EPSRC funded program grant. The IMPACT (Implantable Microsystems for Personalised Anti-cancer Therapy) project aimed to develop miniaturised sensors that could be implanted into solid tumours to measure intra-tumoural oxygen and pH. My role was to develop novel small and large animal models which would validate sensor functionality. The large animal work involved the development of an ovine pulmonary adenocarcinoma model.
- As a secondary aim of my PhD I developed novel in vitro radioresistant cell lines which were used to characterise cancer cell radioresistance and identify secreted proteins related to radiation response.
Current research interests
The roles within this job are split between my own research projects, teaching at the Royal (Dick) School of Veterinary Studies and performing surgery for other research groups at the Large Animal Research and Imaging Facility (LARIF) within the University of Edinburgh. Within my surgical role at LARIF I am largely involved with the development of large animal surgical translational models. These studies have included a porcine intestinal anastomosis project, a porcine acute kidney ischaemic and reperfusion injury model, a bovine lymphatic model and an ovine lung tumour model. I continue to be involved with multidisciplinary projects both within and outside the University Edinburgh. I am particularly interested in the development of implantable sensors for a medical uses and continue to work with engineers to develop the IMPACT sensors for human and veterinary applications. I also collaborate with colleagues at the Moredun institute to continue my research into ovine pulmonary adenocarcinoma.Affiliated research centres
- Moredun Research Institute
Current project grants
In vivo validation of novel biomarkers of response to radiotherapy in breast cancer. Chief Scientist Office
Pilot Study to Identify Predictive and Prognostic Biomarkers of Response Radiotherapy in Prostate Cancer . The Urology Foundation.
Development and characterisation of an ovine pulmonary adenocarcinoma model for human lung cancer and veterinary research. Industry funded.
-
Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor Positive Breast Cancer
In:
Clinical Cancer Research
DOI: https://doi.org/10.1158/1078-0432.CCR-21-3189
Research output: Contribution to Journal › Article (Published) -
Exosomes Derived from Radioresistant Breast Cancer Cells Promote Therapeutic Resistance in Naïve Recipient Cells
In:
Journal of personalized medicine
DOI: https://doi.org/10.3390/jpm11121310
Research output: Contribution to Journal › Special issue (E-pub ahead of print) -
Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression
In:
Veterinary Immunology and Immunopathology, vol. 243
DOI: https://doi.org/10.1016/j.vetimm.2021.110363
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A Novel Approach for the Discovery of Biomarkers of Radiotherapy Response in Breast Cancer
In:
Journal of personalized medicine, vol. 11, pp. 796
DOI: https://doi.org/10.3390/jpm11080796
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Tissue- and Liquid-Based Biomarkers in Prostate Cancer Precision Medicine
In:
Journal of personalized medicine
DOI: https://doi.org/10.3390/jpm11070664
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Post-operative monitoring of intestinal tissue oxygenation using an implantable microfabricated oxygen sensor
(15 pages)
In:
Micromachines, vol. 12
DOI: https://doi.org/10.3390/mi12070810
Research output: Contribution to Journal › Article (Published) -
The signal transducer IL6ST (gp130) as a predictive and 2 prognostic biomarker in breast cancer
In:
Journal of personalized medicine
DOI: https://doi.org/10.3390/jpm11070618
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Predictive and Diagnostic Biomarkers of Anastomotic Leakage: A Precision Medicine Approach for Colorectal Cancer Patients
In:
Journal of personalized medicine
DOI: https://doi.org/10.3390/jpm11060471
Research output: Contribution to Journal › Special issue (E-pub ahead of print) -
Current trends in the treatment of HR+/HER2+ breast cancer
(17 pages)
In:
Future oncology, vol. 17, pp. 1665-1681
DOI: https://doi.org/10.2217/fon-2020-0504
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
The importance of the tumour microenvironment and hypoxia in delivering a precision medicine approach to veterinary oncology
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.598338
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor
(12 pages)
In:
Sensing and Bio-Sensing Research, vol. 30, pp. 1-12
DOI: https://doi.org/10.1016/j.sbsr.2020.100375
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.00439
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
In:
Frontiers in Oncology
DOI: https://doi.org/10.3389/fonc.2020.00617
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer
In:
Frontiers in Oncology
DOI: https://doi.org/10.3389/fonc.2020.00628
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Test Structures for Developing Packaging for Implantable Sensors
In:
IEEE Transactions on Semiconductor Manufacturing
DOI: https://doi.org/10.1109/TSM.2020.2987134
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention
In:
Exploration of Targeted Anti-tumour Therapy
DOI: https://doi.org/10.37349/etat.2020.00005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
In vivo validation of a miniaturized electrochemical oxygen sensor for measuring intestinal oxygen tension
(11 pages)
In:
American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 317, pp. G242-G252
DOI: https://doi.org/10.1152/ajpgi.00050.2019
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A Novel Translational Ovine Pulmonary Adenocarcinoma Model for Human Lung Cancer
(17 pages)
In:
Frontiers in Oncology, vol. 9
DOI: https://doi.org/10.3389/fonc.2019.00534
Research output: Contribution to Journal › Article (Published) -
Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research
In:
Frontiers in Oncology, vol. 9
DOI: https://doi.org/10.3389/fonc.2019.00335
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Development and characterisation of acquired radioresistant breast cancer cell lines
In:
Practical radiation oncology, vol. 14
DOI: https://doi.org/10.1186/s13014-019-1268-2
Research output: Contribution to Journal › Article (E-pub ahead of print)