Science Director and Chair of Cancer Biology, Cancer Research UK Edinburgh Centre. Director, MRC Institute of Genetics & Molecular Medicine.
Margaret Frame is a biomedical research scientist with interests in novel cancer mechanisms, as evidenced by deep biology, imaging and new approaches to drug discovery and cancer therapeutics – work that has been funded by five successive CRUK (or predecessor charity) Programme grants and more recently also by an ERC Advanced Investigator Grant.
From 2002-2007, Margaret was Deputy Director of the core funded CRUK Beatson Institute for Cancer Research in Glasgow, after which she moved to the University of Edinburgh (UoE). Currently she is Professor of Cancer Research, Director of the CRUK Edinburgh Cancer Centre and Director of the MRC-IGMM (Institute of Genetics and Molecular Medicine), having recently stepped down as Dean of Research in the College of Medicine and Veterinary Medicine (UoE). Margaret is very active in supporting the scientific careers of early- and mid-stage researchers (the MRC-IGMM has 25 early-career Chancellor’s Fellows, 20 of whom have won personal fellowships or substantial other grant funding). She supports early career researchers, both clinical and non-clinical, an interest that stems from her time as Chairman of the CRUK New Investigator Panel and from her own experiences when building a research career during the ‘young family’ years (3 adult sons). She is currently co-Chair of the Academy of Medical Sciences Careers Committee and member of Lister Institute Scientific Advisory Committee, a Wellcome Trust Expert Review Group and an ERC Funding Panel, as well as chairman, or member, of several international scientific advisory boards.
Margaret was awarded the Tenovus Medal in 1999, and was elected a Fellow of the Royal Society of Edinburgh in 2002, an EMBO Member in 2007 and a Fellow of the Academy of Medical Sciences in 2009. She was awarded the Chancellor’s prize for Research - presented by HRH The Princess Royal (the Chancellor of the University of Edinburgh). She recently served as President of the British Association for Cancer Research and Chaired the 2018 National (UK) Cancer Research Institute meeting. She was awarded an OBE in the Queen’s Honours List in 2018 for services to cancer research.
Novel Roles of PRK1 and PRK2 in cilia and cancer biology
A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen
Funding mechanisms risk promoting conscious bias
Trafficking of Adhesion and Growth Factor Receptors and their Effector Kinases
Structure-based design, synthesis and characterization of the first irreversible inhibitor of Focal Adhesion Kinase