Lucija Klaric
UKRI Research Fellow
- MRC Human Genetics Unit
- Institute of Genetics and Molecular Medicine
- College of Medicine and Veterinary Medicine
Contact details
Address
- Street
-
MRC Human Genetics Unit
MRC Institute of Genetics & Molecular Medicine
The University of Edinburgh
Western General Hospital
Crewe Road - City
- Edinburgh
- Post code
- EH4 2XU
Background
Lucija earned her PhD in human genetics at the University of Edinburgh, where she studied genetic regulation of protein glycosylation. Working as a research fellow at the University of Edinburgh and data analyst in Genos Ltd on the project “Methods for Integrated Analysis of Multiple Omics datasets”, she gained insights both in bottom-up pre-processing and analyses of glycomics data, but also in integrating these with genomics and clinical data. She has a general interest in data integration of different omics and has been appointed to a UKRI innovation fellowship in data science to work on linking whole genome and exome sequencing data with different omics in the context of complex traits and diseases.
Qualifications
MSc (2012, Molecular Biology, Faculty of Science, University of Zagreb)
PhD (2018, Human Genetics, MRC HGU IGMM, University of Edinburgh)
Undergraduate teaching
Supervisor of the Phenotype Imputation honours project
Current PhD students supervised
Arianna Landini - https://www.ed.ac.uk/profile/arianna-landini
Zhe Huang - https://www.ed.ac.uk/profile/zhe-huang
Current research interests
My main research focus has been genetic regulation of omics traits. I work on associations of phenomics and proteomics and whole genome and exome sequencing data, with a special focus on rare variants.Past research interests
In past I mostly focused on genetic regulation of protein glycosylation, association of glycans with wide variety of health-related traits. As part of the EU FP7 project Methods for Integrated Analysis of Multiple Omics Datasets (MIMOmics) I gained experience in study design and assessing the influence of different data pre-processing approaches on downstream statistical analyses, as well as in integration of glycomics and other omics datasets.Current project grants
UKRI Innovation/Rutherford Fund Fellowship
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
In:
Communications biology, vol. 5, pp. 580
DOI: https://doi.org/10.1038/s42003-022-03448-z
Research output: Contribution to Journal › Article (Published) -
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
In:
Nature Genetics
DOI: https://doi.org/10.1038/s41588-022-01062-7
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations
In:
Molecular Metabolism, pp. 101509
DOI: https://doi.org/10.1016/j.molmet.2022.101509
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes
In:
Cardiovascular diabetology, vol. 21
DOI: https://doi.org/10.1186/s12933-022-01493-w
Research output: Contribution to Journal › Article (Published) -
Genetic Landscape of the ACE2 Coronavirus Receptor
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.057888
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mapping the human genetic architecture of COVID-19
In:
Nature
DOI: https://doi.org/10.1038/s41586-021-03767-x
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function
(12 pages)
In:
Human Molecular Genetics, vol. 30, pp. 1259-1270
DOI: https://doi.org/10.1093/hmg/ddab072
Research output: Contribution to Journal › Article (Published) -
Variants associated with HHIP expression have sex-differential effects on lung function
In:
Wellcome Open Research , vol. 5, pp. 111
DOI: https://doi.org/10.12688/wellcomeopenres.15846.1
Research output: Contribution to Journal › Article (Published) -
Variants associated with HHIP expression have sexdifferential effects on lung function
(20 pages)
In:
Wellcome Open Research , vol. 5, pp. 1-20
DOI: https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Research output: Contribution to Journal › Article (Published) -
Genetic mechanisms of critical illness in Covid-19
In:
Nature, vol. n/a
DOI: https://doi.org/10.1038/s41586-020-03065-y
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Genetic mechanisms of critical illness in Covid-19
DOI: https://doi.org/10.1101/2020.09.24.20200048
Research output: › Working paper (Published) -
Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies
In:
Scientific Reports, vol. 10, pp. 10486
DOI: https://doi.org/10.1038/s41598-020-67001-w
Research output: Contribution to Journal › Article (Published) -
Choosing proper normalization is essential for discovery of sparse glycan biomarkers
In:
Molecular Omics, vol. 16
DOI: https://doi.org/10.1039/c9mo00174c
Research output: Contribution to Journal › Article (Published) -
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases
In:
Science Advances, vol. 6
DOI: https://doi.org/10.1126/sciadv.aax0301
Research output: Contribution to Journal › Article (Published) -
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions
(30 pages)
In:
PLoS Genetics, vol. 15, pp. 1-29
DOI: https://doi.org/10.1371/journal.pgen.1008480
Research output: Contribution to Journal › Article (E-pub ahead of print)