Juan-Carlos Acosta
Chancellor's Fellow - Cellular Senescence and Tumour Suppression
- Cancer Research UK Edinburgh Centre
- MRC Institute of Genetics & Molecular Medicine
Contact details
Address
- Street
-
Cancer Research UK Edinburgh Centre
MRC Institute of Genetics & Molecular Medicine
The University of Edinburgh
Western General Hospital
Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XR
Background
Juan Carlos Acosta was born in Gerona, Spain. He studied Pharmacy at the University of Salamanca where he did a placement at the laboratory of Ester Caballero in the department of organic and pharmaceutical chemistry working in the synthesis of new Anthracyclines with antineoplastic activity. Later in 1997 he moved to Santander to the laboratory of Professor Javier Leon in the department of molecular biology first as a research assistant and later as a PhD student where he completed a doctoral thesis in the study of the functional interactions between p27 and MYC in erythroid differentiation of leukemia cells. In 2006 he moved to London to complete a postdoctoral training in the laboratory of Jesus Gil at the MRC Clinical Sciences Centre working in several aspects of the regulation of senescence and the identification of new tumour suppressor pathways. Since 2013 he is in Edinburgh where he directed his independent research group as Chancellor’s Fellow at the ECRC, as part of the MRC-IGMM in the University of Edinburgh, interested in the role of senescence in remodelling of the tumour microenvironment and tumour suppression
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Notch mediates secondary senescence
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2019.03.104
Contribution to journal › Article (Published) -
Nuclear pore density controls heterochromatin reorganization during senescence
In:
Genes & Development, vol. 33, no. 3-4, pp. 144-149
DOI: https://doi.org/10.1101/gad.321117.118
Contribution to journal › Article (E-pub ahead of print) -
PHD3 regulates p53 protein stability by hydroxylating Proline 359
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2018.06.108
Contribution to journal › Article (Published) -
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
In:
Nature Communications, vol. 9, no. 1
DOI: https://doi.org/10.1038/s41467-018-03299-5
Contribution to journal › Article (Published) -
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition
In:
Journal of Experimental Medicine
DOI: https://doi.org/10.1084/jem.20160855
Contribution to journal › Article (E-pub ahead of print)