Juan-Carlos Acosta
Chancellor's Fellow - Cellular Senescence and Tumour Suppression
- Cancer Research UK Edinburgh Centre
- MRC Institute of Genetics & Molecular Medicine
Contact details
- Email: Juan-Carlos.Acosta@ed.ac.uk
Address
- Street
-
Cancer Research UK Edinburgh Centre
MRC Institute of Genetics & Molecular Medicine
The University of Edinburgh
Western General Hospital
Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XR
Background
Juan Carlos Acosta was born in Gerona, Spain. He studied Pharmacy at the University of Salamanca where he did a placement at the laboratory of Ester Caballero in the department of organic and pharmaceutical chemistry working in the synthesis of new Anthracyclines with antineoplastic activity. Later in 1997 he moved to Santander to the laboratory of Professor Javier Leon in the department of molecular biology first as a research assistant and later as a PhD student where he completed a doctoral thesis in the study of the functional interactions between p27 and MYC in erythroid differentiation of leukemia cells. In 2006 he moved to London to complete a postdoctoral training in the laboratory of Jesus Gil at the MRC Clinical Sciences Centre working in several aspects of the regulation of senescence and the identification of new tumour suppressor pathways. Since 2013 he is in Edinburgh where he directed his independent research group as Chancellor’s Fellow at the ECRC, as part of the MRC-IGMM in the University of Edinburgh, interested in the role of senescence in remodelling of the tumour microenvironment and tumour suppression
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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage
(16 pages)
In:
Science Translational Medicine, vol. 14
DOI: https://doi.org/10.1126/scitranslmed.abj4375
Research output: Contribution to Journal › Article (Published) -
Toll-like receptor orchestrates a tumor suppressor response in non-small cell lung cancer
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2022.111596
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Myc sensitises cells to apoptosis by driving energetic demand
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-022-32368-z
Research output: Contribution to Journal › Article (E-pub ahead of print) -
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma
(12 pages)
In:
Cancer Research, vol. 82, pp. 1548-1559
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2556
Research output: Contribution to Journal › Article (Published) -
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
In:
Cell Death & Differentiation (CDD)
DOI: https://doi.org/10.1038/s41418-021-00917-6
Research output: Contribution to Journal › Article (E-pub ahead of print)