Professor Joe Marsh
Personal Chair of Computational Protein Biology
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Email: joseph.marsh@ed.ac.uk
Background
I joined the MRC Human Genetics Unit as a Chancellor’s Fellow in 2014 in order to start an independent research group. We use computational methods to study the role of protein complexes in normal biological process and in human disease.
Prior to this, I was a postdoc in the group of Dr Sarah Teichmann at the MRC Laboratory of Molecular Biology and the EMBL European Bioinformatics Institute, supported by HFSP and EMBO fellowships. My postdoctoral research focused on using structural bioinformatic approaches to study protein flexibility and the structure, assembly and evolution of protein complexes.
I completed my PhD in 2009 in the group of Dr Julie Forman-Kay at the University of Toronto and the Hospital for Sick Children. My research there involved both experimental and computational characterisation of the structure and dynamics of intrinsically disordered proteins, and how these properties are related to their interactions with other proteins.
Qualifications
Bachelor of Science, University of British Columbia Doctor of Philosophy (PhD), University of Toronto Structural Characterization of Disordered States of Proteins
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Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins
(2 pages)
In:
Current Biology, vol. 27, pp. R17-R18
DOI: https://doi.org/10.1016/j.cub.2016.11.050
Research output: Contribution to Journal › Article (Published) -
Ligand binding site structure influences the evolution of protein complex function and topology
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2018.02.085
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Role of protein Complexes in Human Genetic Disease
In:
Protein Science, vol. 28
DOI: https://doi.org/10.1002/pro.3667
Research output: Contribution to Journal › Review article (Published) -
Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
(17 pages)
In:
Genes and Development, vol. 33, pp. 1031-1047
DOI: https://doi.org/10.1101/gad.327494.119
Research output: Contribution to Journal › Article (Published) -
Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction
In:
Genetics in Medicine
DOI: https://doi.org/10.1038/s41436-019-0685-9
Research output: Contribution to Journal › Article (Published)