Miracle Ozzoude

Thesis title: Endotyping neurodegeneration through the eye using multimodal retinal imaging

MRC DTP in Precision Medicine

Year of study: 1

  • Institute for Regeneration and Repair

Contact details

PhD supervisors:

Address

Street

Robert O Curle Suite
Institute for Regeneration and Repair
Edinburgh BioQuarter
4-5 Little France Drive

City
Edinburgh
Post code
EH16 4UU

Biography

Background

First year PhD student investigating the early detection of neurodegenerative diseases through the eye using multimodal retinal and brain imaging.

Qualifications

MA in Psychology and Neuroscience (specialisation: Brain, Behaviour, and Cognitive Sciences), York University, Toronto, ON, Canada (2023)

HBSc in Neuroscience and Psychology, University of Toronto, ON, Canada (2016)

Research summary

The goal of my Precision Medicine project is to endotype neurodegeneration through the eye using multimodal retinal imaging. This is because Neurodegenerative diseases affect millions of people worldwide and are a global public health challenge. Whilst no cure currently exist, early and accurate diagnosis provide a chance for quicker and optimal treatment that may help to prevent or slow disease progression, resulting in symptoms relief to enhance patients’ quality of life. Thus, I am interested in using the eye as a window to neurodegeneration and neurovascular dysfunction. In collaboration with our industry partner, Heidelberg Engineering, our aim is to assess novel eye biomarkers that are quick, less invasive, affordable, more accurate, and more tolerable by patients. In combination with other biomarkers like neuroimaging and fluid, we hope to develop a better understanding, differentially diagnose, and monitor these diseases, and ultimately develop new therapeutic targets.

Current research interests

1. Ageing 2. Neurodegeneration/Neurodegenerative diseases 3. Multiple Sclerosis 4. Neuroimaging 5. Retinal imaging 6. Fluid biomarker 7.Optimal coherence tomography (OCT)/ OCT- Angiography/Scanning Laser Ophthalmoscopy (SLO) 8. Cerebral small vessel disease 9. White matter lesions 10. Brain atrophy 11. Vascular risk factors

Past research interests

1. Neuropsychiatric symptoms 2. Cognitive-motor Integration 3. Social Cognition 4. Traumatic Brain Injury/Concussion

Conference details

  1. Ozzoude, M., et al.Neuroanatomical correlates  ofVisual Working Memory and Visual Attention as measured by Perceptual-Cognitive Task in Post-Concussion Syndrome. Poster presented at the 4th Annual Canadian Sports Concussion Project Symposium, Toronto, Ontario, Canada. January 2016.

  2. Ozzoude, M., et al. The Effects of Illness Severity, Cognition, and Estimated Antipsychotic Dopamine Receptor Occupancy on Insight into the Illness in Schizophrenia: An Analysis of Clinical Antipsychotic Trails of Intervention Effectiveness (CATIE) Data. Poster presented at the 46th meeting of the Ontario Psychology Undergraduate Thesis Conference, Wilfrid Laurier University, Waterloo, Ontario, Canada. May 2016.

  3. Ozzoude, M., et al. Improved FreeSurfer Parcellation in Structural MRI in VCI population with Inclusion of Mask for Infarcts and White Matter Hyperintensities. Poster presented at the 16th Annual Imaging Network Ontario, Toronto, Ontario, Canada. March 2018.

  4. Haddad, S.M.H.,Scott, C.JM., Ozzoude, M.,et al.Brain Diffusion Tensor Imaging Metrics in Cerebral Tissues and Ischemic Lesions. Poster presented at the 16th Annual Imaging Network Ontario, Toronto, Ontario, Canada. March 2018.

  5. Haddad, S.M.H.,Scott, C.JM.,Ozzoude, M., et  al. Brain DiffusionTensor Imaging Metrics in Cerebral Tissues and Ischemic Lesions in Vascular Cognitive Impairment. Poster presented at the 2018 Annual Alzheimer Association International Conference (AAIC), Chicago, Illinois, USA. July 2018.

  6. Kapoor, A., Symons, S., Bartha, R., Scott, C.J.M., Black, S.E., Gao, F., Ozzoude, M., et al. Utility of MRI in the Assessment of AD/MCI – Findings from Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study. Poster presented at the 2018 Annual Alzheimer Association International Conference (AAIC), Chicago, Illinois, USA. July 2018.

  7. Goubran, M., Zukotynski, K., Adamo, S., Bocti, C., Borrie, M., Chertkow, H., Frayne, R., Gao, F., Hsiung, R., Kiss, A., Laforce, Jr.R., Noseworthy, M.D., Ozzoude, M., et al. Relationship between Amyloid load, White Matter Microstructure and Cognitive performance in Patients with significant White Matter Disease. Poster presented at the 9th International Conference of the International Society of Vascular Behavioural and Cognitive Disorders (VASCOG), Hong Kong. November 2018.

  8. Haddad, S.M.H., Scott, C.J.M, Arnott, S.R., Ozzoude, M., et al. Brain Activity Mapping Based on Low-Frequency Fluctuations of the Resting-State BOLD Signal: Comparing Healthy Elderly to Mild Cognitive Impairment and Alzheimer’s Disease. Poster presented at the 27th International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Quebec, Canada. May 2019. https://submissions.mirasmart.com/ISMRM2019/ViewSubmissionPublic.aspx?sei=I4oLefQIc.

  9. Goubran, M., Ntiri, E., Akhavein, H., Holmes, M.F., Nestor, S., Ramirez, J., Adamo, S., Ozzoude, M., et al. Hippocampal Segmentation for Brains with Extensive Atrophy using Three-dimensional Convolutional Neural Networks. Oral and digital presentation at the 27th International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Quebec, Canada. May 2019.

  10. Haddad, S.M.H, Pieruccini-Faria, F.,Scott, C.J.M., Arnott, S.R.,Ozzoude, M., et al. Brain Perivascular Space Volume is associated with Poor Gait Reserve in Vascular Cognitive Impairment. Poster presented at the 39th Annual Canadian Geriatrics Society Scientific Meeting, Halifax, Nova Scotia, Canada. May 2019.

  11. Taghdiri, F., Multani, N., Ozzoude, M., et al. Serum Neurofilament Light Protein as a Potential Biomarker of Neurodegeneration in Former Professional Athletes with Multiple Concussions. Oral presentation at the 2019 Annual Alzheimer Association International Conference (AAIC), Los Angeles, USA. July 2019.

  12. Haddad, S.M.H., Scott, C.J.M., Arnott, S.R., Ozzoude, M.,et al. Frequency-Dependent Resting-State Brain Activity Mapping: Comparing Healthy Elderly to Mild Cognitive Impairment and Alzheimer’s Disease. Poster presented at the 2019 Annual Alzheimer Association International Conference (AAIC), Los Angeles, USA. July 2019.

  13. Ozzoude, M., et al. Investigating the contribution of White Matter Hyperintensities to Neuropsychiatric Symptoms and Social Cognition deficits in Patients with Neurodegenerative Diseases. Poster presented at the 10th Canadian Conference on Dementia (CCD), Quebec city, Quebec, Canada. October 2019.

  14. Goubran, M., Ozzoude, M., et al. Amyloid Binding is associated with markers of White Matter Microstructure in Patients with significant White Matter Disease. Poster presented at the 14th Human Amyloid Imaging (HAI) Conference, Miami, Florida, USA. January 2020.

  15. Mojiri, F.P., Ntiri, E.E., Holmes, M.F, Adamo, S., Ramirez, J., Gao, F., Ozzoude, M., et al. Uncertainty Estimation of White Matter Hyperintensity Segmentation using a Bayesian 3D UNet. ePoster presented at Human Brain Mapping (OHBM) Annual Meeting, Montreal, Canada. July 2020.

  16. Haddad, S.M.H., Scott, C.J.M., Arnott, S.R., Ozzoude, M., et al. Reduced Neuronal Activity in Alzheimer’s Disease and Mild Cog- nitive Impairment Measured by Resting State fMRI. ePoster presented at the 2020 Annual Alzheimer Association International Conference (AAIC), Amsterdam, Netherlands. July 2020.

  17. Haddad, S.M.H., Scott, C.J.M., Ozzoude, M., et al. Fractional Anisotropy in White Matter Hyperintensities is Linked to Asso- ciative Memory Performance. ePoster presented at the 2020 Annual Alzheimer Association International Conference (AAIC), Amsterdam, Netherlands. July 2020.

  18. Geng, J., Honjo, K. Gao, F., Ramirez,  J., Holmes, M.F.,  Adamo, S., Ozzoude, M., et al. Secondary thalamic atrophy related to brain infarction may contribute to post-stroke cognitive impairment. ePoster presented at the 2021 International Stroke Conference,March 2021.

  19. Ottoy, J., Ozzoude, M., et al. Amyloid-independent vascular contributions to cortical atrophy and cognition in a multi-centermixed cohort with low to severe small vessel disease. ePoster presented at the 2021 Annual Alzheimer Association International Conference (AAIC), Denver, USA. July 2021.

  20. Yu, D., Taha, A.Y., Pedersen, T., Ramirez, J., Goubran, M., Ozzoude, M. et al. Serum Oxylipins Indicate Subcortical Ischemic Vascular Disease in Patients with Clinical Stroke. ePoster presented at the 2021 Annual Alzheimer Association International Conference (AAIC), Denver, USA. July 2021.

  21. Haddad, S.M.H., Scott, C.J.M., Arnott, S.R., Ozzoude, M., et al. Comparison of Neuronal Activity Profiles in Alzheimer’s Disease and Frontotemporal Dementia Measured by Resting-state fMRI. ePoster presented at the 2021 Annual Alzheimer Association International Conference (AAIC), Denver, USA. July 2021.

  22. Haddad,S.M.H., Scott,C.J.M., Ozzoude,M., et al. Disintegration of Anterior Thalamic Radiation Fibers in Cerebrovascular Disease Subjects with Periventricular White Matter Hyperintensities Leads to Lower Executive Function Performance. ePoster presented at the 2021 Annual Alzheimer Association International Conference (AAIC), Denver, USA. July 2021.

  23. Ottoy, J.,  Ozzoude, M., et al. Effects of vascular burden on cognition are mediated by atrophy,  amyloid, and glucose metabolism: a multi-centre mixed cohort of small vessel disease and Alzheimer’s pathology. Virtual oral presentation at the International Conference of the International Society of Vascular Behavioural and Cognitive Disorders (VASCOG). September 2021.

  24. Coughlan, G., McLaughlin, P., Sunderland, K., Borrie, M., Fischer, C., Frank, A., Freedman, M., Kumar, S., Pasternak, S., Pollock, B., Rajji, T., Seitz, D., Tang-Wai, D., Tartaglia, M.C., Dewar, J., Kwan, D., Tan, B., Grimes, D., Jog, M., Lang, T., Marras, C., Steeves, T., Bulman, D., Dilliott, A., Ghani, M., Hegele, R., Robinson, J., Rogaev, E., Farhan, S., Bartha, R., Nanayakkara, N., Ramirez, J., Scott, C., Symons, S., Berezuk, C., Holmes, M., Adamo, S., Ozzoude, M., et al. (2021). Distinct memory networks in Parkinson’s disease (PD) and Alzheimer’s disease (AD): Effects of APOE. Virtual poster presentation at the International Congress of Parkinson’s Disease and Movement Disorders. September 2021.

  25. Ottoy,J.*,Ozzoude, M.*,et al. Relationship between amyloid-PET binding, white matter microstructure and cognition in a mixed cohort of small vessel disease and Alzheimer’s pathology. Poster to be presented at the International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD), Barcelona, Spain. March 2022. *shared first authorship

  26. Vasilevskaya, A., Taghdiri, F., Multani, N., Ozzoude, M., et al. Tau-PET in retired contact sport athletes. 2022 Annual Alzheimer Association International Conference (AAIC),San Diego, USA. July 2022.

  27. Ozzoude, M., et al. Impaired Cognitive Motor Integration, Persistent Symptoms after Concussion, and Brain Function. 10th Annual Concussion Research Symposium, Toronto, ON, Canada. April 2023.

  28. Ozzoude, M.,et al. BrainStructure and Network Function are Related to Impaired Cognitive-Motor Integration in Working-aged Adults with Persistent Symptoms After Concussion. Canadian Concussion Network 3rd annual meeting, Calgary, AB, Canada. June 2023.

  1. Ozzoude, M., et al. (2023). White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases. Alzheimer’s Research & Therapy. https://doi.org/10.1186/s13195-023-01257-y

  2. Dilliott, A.A., Berberian, S.A., Sunderland, K.M., Binns, M.A., Zimmer, J., Ozzoude, M., et al. (2023). Rare neurovascular genetic and imaging markers across Neurodegenerative diseases. Alzheimer’s & Dementia. https://doi.org/10.1002/alz.13316

  3. Ottoy,J.*,Ozzoude,M.*, et al.(2023). Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease Journal of Cerebral Blood Flow and Metabolism. *shared first authorship. https://doi.org/10.1177/0271678X231152001

  4. Geng, J., Gao, F., Ramirez, J., Honjo, K., Holmes, M.F., Adamo, S., Ozzoude, M., et al. (2023). Secondary thalamic atrophy related to brain infarction may contribute to post-stroke cognitive impairment. Journal of Stroke and Cerebrovascular Disease. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106895

  5. Meng, Y., Goubran, M., Rabin, J.S., McSweeney, M., Ottoy, J., Pople, C., Huang, Y., Storace, A., Ozzoude, M., et al. (2023). Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound. Brain. https://doi.org/10.1093/brain/awac459

  6. Yu, D., Liang, N., Zebarth, J., Shen, Q., Ozzoude, M., et al.(2022).Soluble epoxide hydrolase derived linoleic acid oxylipins, small vessel disease markers and neurodegeneration in stroke. Journal of the American Heart Association. https://doi.org/10.1161/JAHA.122.026901

  7. Haddad, S.M.H., Scott, C.J.M, Ozzoude, M., et al.(2022).Comparison of Diffusion Tensor Imaging Metrics in Normal-Appearing White Matter to Cerebrovascular Lesions and Correlation with Cerebrovascular Disease Risk Factors and Severity. International Journal of Biomedical Imaging. https://doi.org/10.1155/2022/5860364

  8. Ottoy, J., Ozzoude, M., et al. (2022). Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid-PET. Alzheimer’s & Dementia.https://doi.org/10.1002/alz.12750

  9. Vasilevskaya, A., Taghdiri, F., Multani, N., Ozzoude, M., et al. (2022). Investigating the use of plasma pTau181 in retired contact sports athletes. Journal of Neurology. http://dx.doi.org/10.1007/s00415-022-11223-7

  10. Ramirez, J.*, Berberian, S.*, Breen, D.P., Gao, F., Ozzoude, M., et al (2022). Small and large MRI-visible perivascular spaces in the basal ganglia of Parkinson’s disease patients. Movement Disorders. https://doi.org/10.1002/mds.29010  *shared first authorship.

  11. Ozzoude, M., et al. (2022). Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases. GeroScience. https://doi.org/10.1007/s11357-022-00539-x

  12. Mojiri, F. P., Biparva, M., Ntiri, E.E., Ramirez, J., Boone, L., Holmes, M., Adamo, S., Gao, F., Ozzoude, M., et al. (2022). Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation. Human Brain Mapping. http://doi.org/10.1002/hbm.25784

  13. Callahan, B.L., Ramakrishnan, N., Shammi, P., Bierstone, D., Taylor, R., Ozzoude, M., et al. (2021). Cognitive and neuroimaging profiles of older adults with ADHD presenting to a memory clinic. Journal of Attention Disorders. 10.1177/10870547211060546

  14. Ramirez, J., Holmes, M.F., Berezuk, C., Kwan, D., Tan, B., Beaton, D., Scott, C.J.M., Ozzoude, M., et al. (2021). MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease. Sleep Medicine. https://doi.org/10.1016/j.sleep.2021.03.043.

  15. Ntiri, E.E., Holmes, M.F., Forooshani, P.M., Ramirez, J., Gao, F., Ozzoude, M., et al. (2021). Improved Segmentation of the Intracranial and Ventricular Volumes in Populations with Cerebrovascular Lesions and Atrophy using 3D CNNs. Neuroinformatics. DOI: 10.1007/s12021-021-09510-1. 

  16. Ozzoude, M.*, et al. (2020). Cortical thickness Estimation in Individuals with Cerebral Small Vessel Disease, Focal atrophy, and Chronic Stroke Lesions. Frontiers in Neuroscience - Brain Imaging Methods. DOI: https://doi.org/10.3389/fnins.2020.598868. *shared first authorship

  17. Taghdiri, F., Multani, N., Ozzoude, M., et al.(2020).Neurofilament Light in Former Athletes: A Potential Biomarker of Neurodegeneration and Progression. European Journal of Neurology. DOI: https://doi.org/10.1111/ene.14251.

  18. Kim, J., Ozzoude, M., et al. (2020). Insight and Medication Adherence in Schizophrenia: An Analysis of the CATIE Data. Neuropharmacology. 10.1016/j.neuropharm.2019.05.011

  19. Davidson, B., Hamani, C., Rabin, J., Goubran, M., Meng, Y., Huang, Y., Baskaran, A., Sharma, S., Ozzoude, M., et al.(2020). Magnetic Resonance-Guided Focused Ultrasound Capsulotomy for Refractory Obsessive Compulsive Disorder and Major Depressive Disorder: Clinical and Imaging Results From Two Phase I Trials. Molecular Psychiatry.10.1038/s41380-020-0737-1

  20. Ramirez, J., Holmes, M.F., Scott, C.J.M., Ozzoude, M., et al. (2020). Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI methods & outcome measures. Frontiers in Neurology. DOI: https://doi.org/10.3389/fneur.2020.00847.

  21. Kapoor, A., Bartha, R., Black, S.E., Borrie, M., Freedman, M., Gao, F., Herrmann, N., Ozzoude, M., et al. (2020). Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer’s Disease Dementia – Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over Past 10 Years. Journal of Alzheimer’s Disease. DOI: http://doi.org/10.3233/JAD-191097.

  22. Ramirez, J., Dilliott, A.A., Binns, M.A., Breen, D.P., Evans, E.C., Beaton, D., McLaughlin, P.M., Kwan, D., Holmes, M.F., Ozzoude, M., et al. (2020). Parkinson’s disease, NOTCH3 genetic variants, and white matter hyperintensities. Movement Disorders. https://doi.org/10.1002/mds.28171.

  23. Ozzoude, M., et al.(2019). The Effects of Illness Severity, Cognition, and Estimated Antipsychotic Dopamine Receptor Occupancy on Insight into the Illness in Schizophrenia: An Analysis of Clinical Antipsychotic Trails of Intervention Effectiveness (CATIE) data. Progress in NeuroPsychopharmacology and Biological Psychiatry, 89, 207-213. 10.1016/j.pnpbp.2018.08.033

  24. Haddad, M.S.S., Scott, C.J.M., Ozzoude, M., et al. (2019). Comparison of Quality Control Methods for Automated Diffusion Tensor Imaging Analysis Pipelines. PLOS ONE, 14(12), e0226715. DOI: https://doi.org/10.1371/journal.pone.0226715.

  25. Goubran, M., Ntiri, E., Akhavein, H., Holmes, M.F., Nestor, S., Ramirez, J., Adamo, S., Ozzoude, M., et al. (2019). Hippocampal Segmentation for Brains with Extensive Atrophy using Three-dimensional Convolutional Neural Networks. Human Brain Mapping. DOI: https://doi.org/10.1002/hbm.24811.

  26. Pothier, D. D., Shah, P., Quilty, L., Ozzoude, M., et al. (2018). Association Between Catastrophizing and Dizziness-Related Disability Assessed with the Dizziness Catastrophizing Scale. JAMA Otolaryngology – Head & Neck Surgery, 144(10), 906-912. DOI:http://dx.doi.org/10.1001/jamaoto.2018.1863.

  27. Gerretsen, P., Takeuchi, H., Ozzoude, M., et al. (2017). Insight into Illness and its Relationship to Illness severity, Cognition and Estimated Antipsychotic Dopamine Receptor Occupancy in Schizophrenia: An Antipsychotic Dose Reduction Study. Psychiatry Research, 251, 20-25. DOI: https://doi.org/10.1016/j.psychres.2017.01.090.

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