E. Elizabeth Patton
Group Leader/Personal Chair of Chemical Genetics
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Tel: +44 (0)131 651 8500
- Email: E.Patton@.ed.ac.uk
Address
- Street
-
MRC Human Genetics Unit
Institute of Genetics and Cancer
The University of Edinburgh
Western General Hospital Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XU
- Street
-
Cancer Research UK Edinburgh Centre
Institute of Genetics and Cancer
The University of Edinburgh
Western General Hospital
Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XR
Background
Dr Patton received a BSc Honours degree from King’s College at Dalhousie University, and a PhD from the University of Toronto, working with Mike Tyers to discover how E3 ubiquitin ligases control cell division. Following this, Liz received a Human Frontier Science Programme Postdoctoral Fellowship to work with Professor Len Zon at Harvard Medical School, where she developed a zebrafish model for melanoma. Her lab uses chemical genetic approaches in zebrafish to investigate gene-drug interactions in melanocyte development, as well as in melanoma biology. Dr Patton is a Handling Editor at Disease Models and Mechanisms (Company of Biologists, Cambridge UK), and serves as an editorial board member for Pigment Cell and Melanoma Research (Wiley). Dr Patton was the founding President of the Zebrafish Disease Models Society (2013-2015) and currently serves as a Board member, and is an elected member of the Young Academy of Scotland at the Royal Society of Edinburgh, and the European Society of Pigment Cell Research. Dr. Patton’s research is funded by the Medical Research Council, the European Research Council, the Wellcome Trust, and a L’Oréal Paris USA–MRA Team Science Award for Women in Scientific Research.
Qualifications
Bachelor of Science, Dalhousie University, Canada Doctor of Science, University of Toronto
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Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease
(16 pages)
In:
Cancer Research, vol. 79, pp. 5769-5784
DOI: https://doi.org/10.1158/0008-5472.CAN-19-0037
Research output: Contribution to Journal › Article (Published) -
PRL3-DDX21 transcriptional control of endolysosomal genes restricts melanocyte stem cell differentiation
(16 pages)
In:
Developmental Cell, vol. 54, pp. 317-332.E9
DOI: https://doi.org/10.1016/j.devcel.2020.06.013
Research output: Contribution to Journal › Article (Published) -
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
In:
Nature Reviews Drug Discovery
DOI: https://doi.org/DOI: 10.1038/s41573-021-00210-8
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential
In:
Cell Reports, vol. 38, pp. 110234
DOI: https://doi.org/10.1016/j.celrep.2021.110234
Research output: Contribution to Journal › Article (Published) -
Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
In:
Development
DOI: https://doi.org/10.1242/dev.200277
Research output: Contribution to Journal › Article (E-pub ahead of print)