Dr Tim Regan (Career Track Fellow)
Group Leader
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Background
Dr. Tim Regan's PhD was on innate immune mediated inflammation regulation in the human gastrointestinal tract. This involved siRNA screening, infection assays and many molecular biology techniques. Attracted by the One Health ethos of the Roslin Institute, Dr. Regan moved here in 2014 to begin a postdoc with a Systems Biology group (Professor Tom Freeman's group). This introduced him to bioinformatics and network graphing skills while studying macrophage transcriptomics and honey bee metagenomics. Tim then worked with Genome-scale CRISPR Knock-Out (GeCKO) screening to study host susceptibility/resistance genes (Dr Kenneth Baillie's group). Finally discovering the wonders of aquaculture, Dr. Regan joined Tim Bean’s lab in 2019 working with government and industry stakeholders to improve bivalve culture in the UK.
In 2023, Dr. Regan was awarded a Career Track Fellowship at Roslin to build their own research group investigating invertebrate aquaculture species immunology in the context of industry-relevant challenges.
Current PhD students supervised
Hannah Farley
Kallen Sullivan
Research summary
Dr. Regan's lab is concerned with exploring immune systems of invertebrate aquaculture species in the context of industry relevant diseases. This includes interactions with host-associated microbiomes, environmental stressors and environmental microbiota.
In the foreseeable future, much of this work will focus on how host genetics and environmental stressors affect blue mussel immunology using a whole range of molecular biology and –omics technologies.
-
Chromosome level reference genome for European flat oyster (Ostrea edulis L.)
In:
Evolutionary Applications, vol. 15, pp. 1713-1729
DOI: https://doi.org/10.1111/eva.13460
Research output: Contribution to Journal › Article (Published) -
Systematic comparison of ranking aggregation methods for gene lists in experimental results
In:
Bioinformatics, vol. 38, pp. 4927-4933
DOI: https://doi.org/10.1093/bioinformatics/btac621
Research output: Contribution to Journal › Article (Published) -
Graphia: A platform for the graph-based visualisation and analysis of high dimensional data
In:
PLoS Computational Biology, vol. 18
DOI: https://doi.org/10.1371/journal.pcbi.1010310
Research output: Contribution to Journal › Article (Published) -
Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
(14 pages)
In:
BMC Biology, vol. 20
DOI: https://doi.org/10.1186/s12915-021-01217-8
Research output: Contribution to Journal › Article (Published) -
Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock
DOI: https://doi.org/10.1101/2021.09.10.459580
Research output: › Working paper (Published) -
A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass
In:
Viruses, vol. 13
DOI: https://doi.org/10.3390/v13081574
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Ancestral physical stress and later immune gene family expansions shaped bivalve mollusc evolution
In:
Genome Biology and Evolution, vol. 13
DOI: https://doi.org/10.1093/gbe/evab177
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Potential of genomic technologies to improve disease resistance in molluscan aquaculture
In:
Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376
DOI: https://doi.org/10.1098/rstb.2020.0168
Research output: Contribution to Journal › Article (Published) -
Genetic improvement technologies to support the sustainable growth of UK aquaculture
In:
Reviews in Aquaculture
DOI: https://doi.org/10.1111/raq.12553
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A platform for the graph-based visualisation and analysis of complex data
DOI: https://doi.org/10.1101/2020.09.02.279349
Research output: › Preprint (Published)