Dr Takanori Kitamura

Chancellor's Fellow

Background

I graduated from Hokkaido University (Graduate School of Veterinary Medicine) in Japan in 2000. Subsequently, I completed a PhD study regarding diabetes in Hokkaido University in 2003. I then relocated to Kyoto University (Graduate School of Medicine) and worked as an assistant professor for 7 years. During this time I studied roles of myeloid cells in invasion and metastasis of colon cancer using mouse models. In 2010, I moved to Albert Einstein College of Medicine in NY, and studied macrophage promoting tumour metastasis in mouse models of breast cancer. In 2013, I relocated to MRC Centre for Reproductive Health, University of Edinburgh as a Chancellor’s fellow and started my own lab to study tumour immunology. I have been studying suppressive effects of tumour-associated macrophages on cytotoxic lymphocytes, in particular natural killer (NK) cells, using in vitro and mouse models of metastatic breast cancer. Since 2018, I also work at R(D)SVS to do a translational research focusing on tumour immunity in canine cancer.      

 

Research summary

Solid tumours include a range of immune cells that promote tumour development such as regulatory T (Treg) cell, myeloid derived suppressor cell (MDSC), tumour-associated macrophage (TAM), and neutrophil (TAN). I am interested in their roles in metastatic tumour outgrowth and effects on anti-tumour immune reactions as well as efficacy of immunotherapy.

Current research interests

I have been studying molecular mechanisms behind macrophage mediated NK cell suppression in metastatic tumours using humanized in vitro assays and mouse models of breast cancer. This study aims to identify key factors that can be targeted to improve efficacy of NK cell infusion therapy. I am also studying immune cell profile in canine melanoma and sarcoma especially focusing on the status of CD8+ T cells and macrophages in it, which will provide important information for establishment of better immunotherapeutic strategies.

View all 34 publications on Research Explorer