Dr Andrew Wood
IGC Chancellor's Fellow
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Email: andrew.wood1@ed.ac.uk
Background
Current: Principal Investigator, Sir Henry Dale Fellow and Chancellor's Fellow. MRC Human Genetics Unit, IGC, University of Edinburgh
Key achievements: Uncovered roles for the SMC complex condensin in disease. Provided evidence that the formation of mitotic chromosomes that are competent for segregation is a developmentally regulated process.
Post-Doctoral (2008 - 2011): Sir Henry Wellcome Fellow in the laboratory of Barbara Meyer. UC Berkeley and the Howard Hughes Medical Institute
Key acheivements: Generated the first gene knockouts in animals using transcription activator-like effector nucleases (TALENs). Showed that gene editing nucleases could be applied across species to study the evolution of developmental mechanisms.
Doctoral (2003 - 2007): Kings College London in the laboratory of Rebecca Oakey
Key achievements: Identified novel imprinted regions of the human and mouse genomes. Demonstrated that alternative splicing and polyadenylation can be regulated by epigenetic modification of chromatin.
Qualifications
Doctor of Philosophy (PhD), University of London Bachelor of Science, University of Sheffield
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Targeted genome editing across species using ZFNs and TALENs
In:
Science, vol. 333, pp. 307
DOI: https://doi.org/10.1126/science.1207773
Research output: Contribution to Journal › Article (Published) -
Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells
(5 pages)
In:
Science, vol. 346, pp. 1238-1242
DOI: https://doi.org/10.1126/science.1259587
Research output: Contribution to Journal › Article (Published) -
Condensin II mutation causes T cell lymphoma through tissue-specific genome instability
(14 pages)
In:
Genes and Development, vol. 30, pp. 2173-2186
DOI: https://doi.org/10.1101/gad.284562.116
Research output: Contribution to Journal › Article (Published) -
Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair
In:
PLoS Biology
DOI: https://doi.org/10.1371/journal.pbio.2005595
Research output: Contribution to Journal › Article (Published) -
Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
In:
eLIFE, vol. 11
DOI: https://doi.org/10.7554/eLife.77987
Research output: Contribution to Journal › Article (Published)