David Webb (MD DSc FRCP FRSE FFPM(Hon) FMedSci)
Christison Chair of Therapeutics and Clinical Pharmacology
- Centre for Cardiovascular Science
Contact details
- Tel: 0131 242 9216
- Email: D.J.Webb@ed.ac.uk
- Web: My research group
Address
- Street
-
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My main clinical interests are in hypertension, chronic kidney disease and cardiovascular risk management and I run a European Society of Hypertension (ESH) Hypertension Excellence Centre in Edinburgh, and coordinate hypertension services in Lothian. My research focuses on the pathophysiology of hypertension and renal disease, particularly arterial stiffness and endothelial function, and includes a large body of work on exploiting the endothelin system for patients with vascular disease. My research spans from studies in animal models of human disease to translational, first-in-human and proof-of-principle studies, and large clinical trials. I am keen to see effective treatments introduced into clinical practice.
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Endothelin Receptor Antagonism Improves Lipid Profiles and Lowers PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) in Patients With Chronic Kidney Disease
(8 pages)
In:
Hypertension, vol. 74, no. 2, pp. 323-330
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.12919
Contribution to journal › Article (Published) -
Renal Denervation Therapy for Hypertension: Still on Trial
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315255
Contribution to journal › Editorial (Published) -
Improving medication safety: focus on prescribers and systems
In:
The Lancet, vol. 394, no. 10195, pp. 283-285
DOI: https://doi.org/10.1016/S0140-6736(19)31526-0
Contribution to journal › Comment/debate (Published) -
Pharmacoepidemiology : using randomised control trials and observational studies in clinical decision-making
In:
British Journal of Clinical Pharmacology
DOI: https://doi.org/10.1111/bcp.14024
Contribution to journal › Review article (E-pub ahead of print) -
Endothelin receptor antagonism improves lipid profiles & lowers PCSK9 in patients with chronic kidney disease
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.12919.
Contribution to journal › Article (Published) -
Safety and efficacy of the SNAP 12 hour acetylcysteine regimen for the treatment of paracetamol overdose
In:
EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.04.005
Contribution to journal › Article (Published) -
Retinal fingerprints for precision profiling of cardiovascular risk
In:
Nature Reviews Cardiology
DOI: https://doi.org/10.1038/s41569-019-0205-2
Contribution to journal › Article (Published) -
Endothelins in cardiovascular biology and therapeutics
In:
Nature Reviews Cardiology
DOI: https://doi.org/10.1038/s41569-019-0176-3
Contribution to journal › Review article (Published) -
Endothelin signalling mediates experience-dependent myelination in the CNS
In:
eLIFE, vol. 8
DOI: https://doi.org/10.7554/eLife.49493
Contribution to journal › Article (E-pub ahead of print) -
A novel role for myeloid endothelin-B receptors in hypertension
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehy881
Contribution to journal › Article (Published) -
The pressure natriuresis response is not affected by SGLT2 inhibition in rats with Type 1 diabetes mellitus
Contribution to conference › Poster (Published) -
Attending a social event and consuming alcohol is associated with changes in serum microRNA: a before and after study in healthy adults
In:
Biomarkers, pp. 1-19
DOI: https://doi.org/10.1080/1354750X.2018.1499128
Contribution to journal › Article (Published) -
Long-term Adverse Effects of Paracetamol - a Review
In:
British Journal of Clinical Pharmacology
DOI: https://doi.org/10.1111/bcp.13656
Contribution to journal › Review article (E-pub ahead of print) -
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
In:
The Lancet Diabetes and Endocrinology, vol. 6, no. 6, pp. 464-475
DOI: https://doi.org/10.1016/S2213-8587(18)30071-8
Contribution to journal › Article (E-pub ahead of print) -
Impaired Pressure Natriuresis and Non-Dipping Blood Pressure in Rats with Early Type 1 Diabetes Mellitus : Pressure natriuresis and BP in T1DM
In:
Journal of Physiology
DOI: https://doi.org/10.1113/JP277332
Contribution to journal › Article (Published) -
Endothelial Factors in The Pathogenesis and Treatment of Chronic Kidney Disease Part I: General Mechanisms. A Joint Consensus Statement from the ESH Working Group on Endothelin and Endothelial Factors And The Japanese Society of Hypertension
In:
Journal of Hypertension
DOI: https://doi.org/10.1097/HJH.0000000000001599
Contribution to journal › Article (E-pub ahead of print) -
Endothelial Factors in The Pathogenesis and Treatment of Chronic Kidney Disease Part II: Role in Disease Conditions. A Joint Consensus Statement from the ESH Working Group on Endothelin and Endothelial Factors And The Japanese Society of Hypertension
In:
Journal of Hypertension
DOI: https://doi.org/10.1097/HJH.0000000000001600
Contribution to journal › Article (E-pub ahead of print) -
Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy : A Randomized, Double-Blind, Placebo-Controlled Trial
In:
Drugs, pp. 441-448
DOI: https://doi.org/10.1007/s40268-017-0201-0
Contribution to journal › Article (Published) -
A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease : Rationale and design of the SPIRO-CKD trial
(10 pages)
In:
The American Heart Journal, vol. 191, pp. 37-46
DOI: https://doi.org/10.1016/j.ahj.2017.05.008
Contribution to journal › Article (Published) -
Combination Therapy is superior to Sequential Monotherapy for the Initial Treatment of Hypertension: a double-blind randomised controlled trial
In:
Journal of the American Heart Association, vol. 6
DOI: https://doi.org/10.1161/JAHA.117.006986
Contribution to journal › Article (E-pub ahead of print)