New hub uses microbes to turn trash into treasure

A pioneering new hub is set to transform UK manufacturing by converting industrial waste into valuable, sustainable chemicals and materials.

A man in a laboratory wearing a white coat transferring liquid between two containers
Professor Stephen Wallace harvesting engineered bacteria for analysis. Credit: Edinburgh Innovations

The £14 million Carbon-Loop Sustainable Biomanufacturing Hub (C-Loop) will use microorganisms to transform carbon-based waste usually destined for landfill into next-generation materials including pharmaceuticals and cosmetics.

By harnessing the power of engineering biology, C-Loop aims to make the manufacturing of everyday products – more than 90 per cent of which are manufactured from fossil fuels using unsustainable chemical processes – cleaner and part of a circular economy.

Collaborative project

Engineering biology – an area in which the University of Edinburgh is a UK and global leader - involves the application of engineering principles to biological processes to create new materials, treatments and solutions.

The hub will also establish the UK’s first BioFactory, a dedicated platform for waste analysis, sustainability evaluation and scale-up that will cut emissions, reduce landfill and help to build a fossil-free manufacturing base.

C-Loop is one of four UK-wide centres announced by the Engineering and Physical Sciences Research Council (EPSRC), which is providing £11 million of the funding and is part of UK Research and Innovation (UKRI).

It will be led by Professor Stephen Wallace, UKRI Future Leaders Fellow and Chair of Chemical Biotechnology from the University of Edinburgh, in partnership with the Universities of Manchester, Nottingham and Surrey, University College London and Imperial College.

Supported by Edinburgh Innovations, the University’s commercialisation service, more than 40 industry partners are involved in the hub. These include global companies from across seven industry sectors, national innovation centres such as IBioIC and facilities such as the Edinburgh Genome Foundry and Imperial’s BRC Genomics Facility.

Amid a growing population, diminishing natural resources, and a changing climate, there is now an urgent environmental, industrial and political imperative to rapidly harness engineering biology technologies to defossilise manufacturing and accelerate the UK’s path to net-zero.

C-Loop brings together diverse expertise from across academic disciplines, industrial sectors, and the entire value-chain to drive the growth and scale-up of this emerging technology, unlocking its full climate and economic potential.

Innovation hub

C-Loop’s multidisciplinary research community, which includes microbiologists, chemists, engineers and sustainability experts, will develop innovative supply chains to accelerate the development and commercial adoption of breakthrough technologies.

In doing so, the hub will help support UK-based engineering biology companies, nurture the UK’s capabilities in the area, and prevent talent and economic potential from leaving the country, the team says.

Two white robot arms moving objects
Edinburgh Genome Foundry. Credit: Edinburgh Innovations and Maverick Photography

I'm delighted to be part of the C-Loop team for this ambitious, multi-million-pound project harnessing engineering biology to upcycle waste carbon.

With industry urgently seeking sustainable alternatives to fossil-based inputs, this initiative is critical in driving the transition to above-ground carbon sources.

There’s no time to waste in getting to no waste – this project not only tackles major environmental challenges but also unlocks significant economic opportunities through the production of sustainable chemicals.

These hubs will play a vital role in reshaping manufacturing to help the UK achieve green growth. By combining deep research expertise with real-world partnerships, they will develop the technologies, tools and systems we need for clean, competitive and resilient industries.

C-Loop builds on the University’s sector-leading engineering biology research and innovation. Edinburgh hosts the UK’s largest and most comprehensive group of researchers in the discipline.

Across the University, researchers are working with more than 200 engineering biology-related companies to drive UK innovation, adoption and growth.

In 2023, the UK Government identified engineering biology as one of its five priority areas, and it’s fantastic to see investment into this field: one that offers so much promise for sustainable industry, and an area where the UK can lead globally.

At Edinburgh, we have a host of pioneering, multidisciplinary researchers, and world-leading facilities. We would urge companies to get in touch and work with us as part of this future green industrial revolution.

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2025
Research
Climate and Environmental Crisis