Fuelling inflammation: oxygen, metabolism and neutrophils

Neutrophils are white blood cells central to the immediate immune response to infection and tissue injury. If left unchecked, however, neutrophils contribute to ongoing tissue destruction. This is particularly apparent in the lung, where their presence is associated with injury and contributes to both acute and chronic diseases. 

We currently have no treatments that target neutrophilic inflammation and the resultant disease burden includes major conditions such as chronic obstructive pulmonary disease.

Neutrophils are specially adapted to function where both oxygen and nutrient supplies are low and targeting these special adaptations should allow us to develop new treatments in the future.

During her inaugural lecture, Sarah will discuss research detailing how oxygen and nutrients regulate the inflammatory response.

Following the lecture there will be a reception in the Sophia Jex-Blake common room.

Open to all.