Dr Deborah Hoyle
Lecturer
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Background
I graduated from the University of Cambridge with BA (Hons) Pathology in 1991 and Vet MB, MRCVS in 1994. I spent a year at the University of Oxford studying the epidemiology of human infectious disease, before working for a short period in mixed clinical practice. In 1996, I moved to the Royal (Dick) School of Veterinary Medicine, Edinburgh, to study for a doctorate, investigating the early immune response to Fasciola hepatica infection in cattle (2000). Following this, I joined Professor Mark Woolhouse’s group, initially on a quarantine surveillance project, examining the risk of zoonotic disease importation by pets into the UK and then as a post-doctoral researcher studying the molecular epidemiology of antimicrobial resistant commensal and pathogenic Escherichia coli in beef cattle. From 2005-2015, I took a ten year career break to raise a family. I returned to research in 2015 with a Wellcome Trust Career Re-entry Fellowship investigating the epidemiology of Shiga toxin positive non-O157 E.coli on farms throughout the UK.
My current research focuses on the epidemiology of veterinary and zoonotic pathogens, antimicrobial resistance, emerging disease and One Health.
Qualifications
2000: Doctor of Philosophy (PhD), University of Edinburgh, "Bovine immune responses to the common liver fluke, Fasciola hepatica, during the early stages of infection"
1995: Master of Arts, University of Cambridge
1994: Bachelor of Veterinary Medicine, University of Cambridge
1991: Bachelor of Arts (Pathology), University of Cambridge
Professional Qualifications
1994: Member of the Royal College of Veterinary Surgeons, MRCVS
Responsibilities & affiliations
Member of the Royal College of Veterinary Surgeons (MRCVS)
Postgraduate teaching
- Course organiser for the Applied Epidemiology and Surveillance for Conservation Medicine course, part of the Conservation Medicine MVetSci Programme
- Emerging Infectious Disease week for the Introduction to One Health course, part of the One Health MSc Programme
Open to PhD supervision enquiries?
Yes
Research summary
Molecular epidemiology of zoonotic and emerging pathogens, antimicrobial resistance, disease surveillance and control, One Health.
Current research interests
I am a qualified veterinarian and researcher, with research interests in the One Health field, focussing on the epidemiology of veterinary pathogens and zoonoses, antimicrobial resistance (AMR) and emerging disease. My current projects focus on the molecular epidemiology of foodborne zoonotic pathogens Shiga-toxin non-O157 Escherichia coli in cattle, the role of mobile genetic elements in the dissemination and retention of AMR genes in livestock, and the impact of withdrawing therapeutic levels of zinc oxide supplementation during piglet weaning on stakeholder antibiotic use and on-farm AMR gene carriage. As a veterinarian, I have further interests in the epidemiology and control of endemic disease in livestock and the impact of disease on animal welfare.Current project grants
03/2024 - 02/2027: "Intended and unintended consequences of the ZnO ban from pig diets on antimicrobial resistance, post-weaning diarrhoea and the microbiome"; Hoyle D (PI), Stevens M, Muwonge A, Oyama L, Kyriazakis I, Creevey C, Anjum M, Abu Oun M, Beechener E; BBSRC (£1.3 M)
Past project grants
09/2022 - 12/2023: "Management of post-weaning diarrhoea and the implications for AMR in response to the upcoming ban on zinc supplementation in pigs"; Hoyle D (PI), Anjum M, Ekiri A, Stevens M, Kyriazakis I, Beechener E, Wheelhouse N; BBSRC (£252 k)
03/2015 - 05/2022: "Prevalence and diversity of Shiga-toxin and non-O157 Escherichia coli carriage in cattle"; Hoyle D (PI), Wellcome Trust Career Re-entry Fellowship (£518 k)
-
High prevalence and factors associated with the distribution of the integron intI1 and intI2 genes in Scottish cattle herds
In:
Frontiers in Veterinary Science, vol. 8
DOI: https://doi.org/10.3389/fvets.2021.755833
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Prevalence and epidemiology of non-O157 Escherichia coli serogroups O26, O103, O111, O145 and Shiga toxin gene carriage in Scottish cattle, 2014-2015.
In:
Applied and Environmental Microbiology
DOI: https://doi.org/10.1128/AEM.03142-20
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Zoonotic causes of febrile illness in malaria endemic countries: a systematic review
In:
The Lancet Infectious Diseases, vol. 20, pp. e27-e37
DOI: https://doi.org/10.1016/S1473-3099(19)30629-2
Research output: Contribution to Journal › Review article (Published) -
Phylogenomic approaches to determine the zoonotic potential of Shiga toxin-producing Escherichia coli (STEC) isolated from Zambian dairy cattle
In:
Scientific Reports, vol. 6
DOI: https://doi.org/10.1038/srep26589
Research output: Contribution to Journal › Article (E-pub ahead of print) -
E. coli O157 on Scottish cattle farms: Evidence of local spread and persistence using repeat cross-sectional data
In:
BMC Veterinary Research, vol. 10, pp. 95
DOI: https://doi.org/10.1186/1746-6148-10-95
Research output: Contribution to Journal › Article (Published) -
The interaction between dam methylation sites and Xba1 restriction digest sites in Escherichia coli O157:H7 EDL933
(6 pages)
In:
Journal of Applied Microbiology, vol. 102, pp. 820-5
DOI: https://doi.org/10.1111/j.1365-2672.2006.03115.x
Research output: Contribution to Journal › Article (Published) -
Antibiotic resistance and molecular epidemiology of Escherichia coli O26, O103 and O145 shed by two cohorts of Scottish beef cattle
(8 pages)
In:
Journal of Antimicrobial Chemotherapy, vol. 59, pp. 403-10
DOI: https://doi.org/10.1093/jac/dkl491
Research output: Contribution to Journal › Article (Published) -
Modelling the epidemiology and transmission of Verocytotoxin-producing Escherichia coli serogroups O26 and O103 in two different calf cohorts
(8 pages)
In:
Epidemiology & Infection, vol. 135, pp. 1316-23
DOI: https://doi.org/10.1017/S0950268806007722
Research output: Contribution to Journal › Article (Published) -
Molecular characterisation of bovine faecal Escherichia coli shows persistence of defined ampicillin resistant strains and the presence of class 1 integrons on an organic beef farm
(8 pages)
In:
Veterinary Microbiology, vol. 115, pp. 250-7
DOI: https://doi.org/10.1016/j.vetmic.2006.01.006
Research output: Contribution to Journal › Article (Published) -
Molecular epidemiology of antimicrobial-resistant commensal Escherichia coli strains in a cohort of newborn calves
(9 pages)
In:
Applied and Environmental Microbiology, vol. 71, pp. 6680-8
DOI: https://doi.org/10.1128%2FAEM.71.11.6680-6688.2005
Research output: Contribution to Journal › Article (Published) -
Age-related decline in carriage of ampicillin-resistant Escherichia coli in young calves
(4 pages)
In:
Applied and Environmental Microbiology, vol. 70, pp. 6927-30
DOI: https://doi.org/10.1128/AEM.70.11.6927-6930.2004
Research output: Contribution to Journal › Article (Published) -
Acquisition and epidemiology of antibiotic-resistant Escherichia coli in a cohort of newborn calves
(5 pages)
In:
Journal of Antimicrobial Chemotherapy, vol. 53, pp. 867-71
DOI: https://doi.org/10.1093/jac/dkh177
Research output: Contribution to Journal › Article (Published) -
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines
(9 pages)
In:
International Journal For Parasitology, vol. 33, pp. 1173-81
DOI: https://doi.org/10.1016/S0020-7519(03)00171-1
Research output: Contribution to Journal › Article (Published) -
The immune response of regional lymph nodes during the early stages of Fasciola hepatica infection in cattle
(9 pages)
In:
Parasite Immunology, vol. 25, pp. 221-9
DOI: https://doi.org/10.1046/j.1365-3024.2003.00627.x
Research output: Contribution to Journal › Article (Published) -
Pre-exposure of cattle to drug-abbreviated Fasciola hepatica infections: the effect upon subsequent challenge infection and the early immune response
(18 pages)
In:
Veterinary Parasitology, vol. 111, pp. 65-82
DOI: https://doi.org/10.1016/S0304-4017(02)00326-6
Research output: Contribution to Journal › Article (Published) -
Survey of parasite infections not endemic to the United Kingdom in quarantined animals
(2 pages)
In:
Veterinary Record, vol. 149, pp. 457-8
DOI: https://doi.org/10.1136/vr.149.15.457
Research output: Contribution to Journal › Article (Published) -
The natural history of syphilis. Implications for the transmission dynamics and control of infection
(16 pages)
In:
Sexually transmitted diseases, vol. 24, pp. 185-200
Research output: Contribution to Journal › Article (Published)