CCBS research spans the spectrum of molecular and cellular biology through to in vivo disease modelling.
We investigate the inner workings of neurons, glia and other cell-types: from the molecules that make up protein complexes at the synapse, through state-of-the-art microscopy of cells in a dish, to the electrophysiology of nerve conduction, and behaviour in the whole animal.
Some of our disease modelling work uses human stem cells:
|Mouse models of inflammation, neurodegeneration & repair||multiple sclerosis||Siddharthan Chandran|
|Large-scale molecular analyses of multiprotein complexes at the synapse (Genes2Cognition)||cognition, learning & memory||Seth Grant|
|New diagnostic tests and biomarkers for prion diseases and other protein mis-folding disorders||prion diseases||Alison Green|
|Cellular and cell-free models of prion replication||prion diseases||Mark Head|
|Molecular analysis of synaptic plasticity, cognition, learning and memory||cognition, learning & memory||Noboru Komiyama|
|The role of mitochondria in neuronal damage||multiple sclerosis||Don Mahad|
|Receptor modulation induced by electrical fields in the synaptic cleft||synaptic biology||Sergiy Sylantyev|
|Mechanisms of memory consolidation and reconsolidation||learning & memory||Szu-Han Wang|